Associate Professor, Department of Cell Biology
B.S., Cell Biology, University of Kansas, Lawrence, Kansas
Ph.D., Neuroscience, University of Florida, Gainesville, Florida
A major area of interest is the development and repair of synapses and circuits in central nervous system. These studies utilize cell culture and the retina as experimental models primarily, but we are working on establishing hippocampal and cortical preparations for these studies as well. One project is focussed on the role of Reelin, an extracellular signaling protein, in regulating the anatomical and synaptic architecture of the rod circuit in the retina (the rod circuit mediates high-sensitivity night vision). A second project is directed at understanding the formation and regeneration of the complex synaptic connections between photoreceptors, the cells in the retina that are responsible for detecting light, and their target cells in the inner retina.
A second, rapidly developing area of interest in the lab is cell migration. We are pursuing studies of growth factors and cytoskeletal elements as regulators of the transition of cells from differentiated, quiescent phenotypes to migratory phenotypes and as regulators of the various modes of migration (collective or directional migration vs. random migration by individual cells). These studies also encompass related cellular behaviors including navigation, adhesion, signaling, trafficking, and proliferation. Specific projects focus on the transition of smooth muscle cells from a normally differentiated and quiescent phenotype to a migratory phenotype, such as occurs during normal or pathological angiogenesis. A second developing project in this area is the role of the microtubule cytoskeleton in regulating neuronal migration, guidance of neuronal processes to their targets and the formation of synapses.
Technical approaches employed in the lab integrate anatomical, pharmacological and molecular means to manipulate and visualize signaling processes, cytoskeletal dynamics and cell behavior. Approaches include shRNA and pharmacological treatments to manipulate expression or activity of specific proteins, fluorescently labeled proteins and biosensors, live cell imaging to directly visualize cellular behaviors. These approaches are complemented by microscopy and immunolabeling at the light, confocal and electron microscopic levels.
University of Oklahoma Health Sciences Center
Department of Cell Biology
P.O. Box 26901
Oklahoma City, OK 73126-0901
Phone: (405) 271-8001 ext. 45514
Fax: (405) 271-3548
David-Sherry@ouhsc.edu David Sherry Interests NIH Biosketch Recent Publications 2010 Phillips_etal_JCompNeurol 2010 Sherry_etal_EurJNeurosci 2010 Wan_etal_Neuron 2011 Ivanovich etal IOVS 2011 Xu etal IOVS 2012 Howard etal ExpCellSci 2012 Kanan etal ExpEyeRes 2012 Rush etal JBC 2012 Wiechmann Sherry JCompNeurol 2012 Xu etal IOVS