Stephenson Cancer Center
Stanton L. Young Biomedical Research Center
Suite # 1403
University of Oklahoma Health Sciences Center
975 N.E., 10th Street
Oklahoma City, OK 73104
PHONE: 405-271-6101 Ext: 52501
Jim and Christy Everest Endowed Chair in Cancer Developmental Therapeutics
Professor of Pathology
Director, Experimental Therapeutics and Translational Cancer Medicine
Chair, Fellowship Training and Mentoring Program
Member, OU Cancer Institute
B.Sc. - Biology, Osmania University
Hyderabad, India, 1985
M.Sc - Microbiology
Hyderabad, India, 1987
Tamil Nadu, India, 1992
Ph.D. - Molecular Biology
All India Institute of Medical Sciences (AIIMS)
New Delhi, India, 1994
Tulane University Medical Center,
New Orleans, LA, 1997
Studies in my laboratory are mainly focused on novel gene-based therapeutics using viral and non-viral vectors with emphasis on translational cancer research. There are two major research areas that are actively being pursued in the laboratory. The first research area is the development and testing of non-viral and nanoparticle-based gene delivery for cancer treatment, and the second research area is studying the antitumor and anti-angiogenic properties of IL-24. Our findings have lead to Phase I clinical trials for treatment of solid tumors.
Memberships & Certifications
Member, American Association for Cancer Research (AACR), 1994-present
Member, American Society of Cell and Gene Therapy (ASCGT), 1995-present
Member, American Society of Clinical Oncology (ASCO), 2007, present
NCI Career Development study section member, 2006-present
Co-Chair, Suicide gene therapy and apoptosis section, American Society of Cell and Gene Therapy (ASCGT), 2008
Sundaram, S., Trivdei, R., Durairaj, C., Ramesh, R., Ambati, B.K., Kompella, U.B. Targeted drug and gene delivery systems for lung cancer therapy. Clin Cancer Res. 2009 Dec 1;15(23):7299-308.
Shanker, M., Willcuts, D., Roth, J.A., Ramesh, R. Drug resistance in lung cancer. Lung Cancer: Targets and Therapy. 1: 1-14, 2010.
Ramesh, R., Ioannides, C.G., Roth, J.A., Chada, S. Adenovirus-mediated interleukin (IL)-24 immunotherapy for cancer. In: Yotnda, P., (ed.), Immunotherapy of Cancer: Methods in Molecular Biology 651: pp: 241-270; Springer Protocols, Humana Press, USA, 2010.
Shanker M, Jin J, Branch CD, Miyamoto S, Grimm EA, Roth J A , Ramesh R. Tumor suppressor gene-based nanotherapy: from test tube to the clinic. J Drug Delivery; 1-10; 2011; doi:10.1155/2011/465845. (Online-only journal)
Li Y, Efferson CL, Ramesh R, Peoples GE, Hwu P, Ioannides CG. A peptidogylcan monomer with the glutamine to serine change and basic peptides bind in silico to TLR-2 (403-455). Cancer Immunol Immunother 2011 Apr;60(4):515-524.
Mandal P, Gao F, Lu Z, Ramesh R, Sanderson Birtwistle J, Ren Z, Chen X, Kaluarachichi K, Ekmekcioglu S, Bast RC, Liao WS, McMurray JS. Potent and selective phosphopeptide mimetic prodrugs targeted to the Src homology 2 (SH2) domain of signal transducer and activator of transcription 3. J Med Chem. May 26, 2011:54(10):3549-63.
Ma LL, Tam JO, Willsey BW, Rigdon D, Ramesh R, Sokolov K, Johnston KP. Selective targeting of antibody conjugated multifunctional nanoclusters (nanoroses) to epidermal growth factor receptors in cancer cells. Langmuir 21 July 2011;27(12):7681-7690.
Yokoyama T, Tam J, Kuroda S, Scott AW, Aaron J, Larson T, Correa AM, Shanker M, Kondo S, Roth JA, Sokolov K, Ramesh R.* EGFR-targeted hybrid plasmonic magnetic nanoparticles synergistically induce autophagy and apoptosis in non-small cell lung cancer cells. PLoS ONE 6 (11): 1-13, e25507, 2011. [doi:10.1371/journal.pone.0025507] Published online 7 November 2011. (online-only journal) *Mentor to T Yokoyama
Lu C, Stewart D, Lee JJ, Ji L, Ramesh R, Jayachandran G, Nunez M, Wistuba II, Erasmus JJ, Hicks ME, Grimm EA, Reuben J, Baladandayuthapani V, Templeton NS, McMannis JD, Roth JA. Phase I clinical trial of systemically administered TUSC2 (FUS1)- nanoparticles mediating functional gene transfer in humans. PLoS One. 2012;7(4):e34833. Epub 2012 Apr 25.
Neves LF, Krais JJ, Van Rite BD, Ramesh R, Resasco DE, Harrison RG: Targeting single-walled carbon nanotubes for the treatment of breast cancer using photothermal therapy. Nanotechnology. 20 Sept 2013;24(37):375104. PMID:23975064