Stephenson Cancer Center Stanton L. Young Biomedical Research CenterSuite # 1403University of Oklahoma Health Sciences Center975 N.E., 10th StreetOklahoma City, OK 73104
PHONE: 405-271-6101 Ext: 52501
Jim and Christy Everest Endowed Chair in Cancer Developmental TherapeuticsProfessor of PathologyDirector, Experimental Therapeutics and Translational Cancer MedicineChair, Fellowship Training and Mentoring ProgramMember, OU Cancer Institute
B.Sc. - Biology, Osmania UniversityHyderabad, India, 1985
M.Sc - MicrobiologyOsmania UniversityHyderabad, India, 1987
DBA Annamalai UniveristyTamil Nadu, India, 1992
Ph.D. - Molecular BiologyAll India Institute of Medical Sciences (AIIMS)New Delhi, India, 1994
Post-Doctoral FellowTulane University Medical Center, New Orleans, LA, 1997
Studies in my laboratory are mainly focused on novel gene-based therapeutics using viral and non-viral vectors with emphasis on translational cancer research. There are two major research areas that are actively being pursued in the laboratory. The first research area is the development and testing of non-viral and nanoparticle-based gene delivery for cancer treatment, and the second research area is studying the antitumor and anti-angiogenic properties of IL-24. Our findings have lead to Phase I clinical trials for treatment of solid tumors.
Memberships & Certifications
Member, American Association for Cancer Research (AACR), 1994-presentMember, American Society of Cell and Gene Therapy (ASCGT), 1995-presentMember, American Society of Clinical Oncology (ASCO), 2007, presentNCI Career Development study section member, 2006-presentCo-Chair, Suicide gene therapy and apoptosis section, American Society of Cell and Gene Therapy (ASCGT), 2008
Yokoyama T, Tam J, Kuroda S, Scott AW, Aaron J, Larson T, Correa AM, Shanker M, Kondo S, Roth JA, Sokolov K, Ramesh R.* EGFR-targeted hybrid plasmonic magnetic nanoparticles synergistically induce autophagy and apoptosis in non-small cell lung cancer cells. PLoS ONE 6 (11): 1-13, e25507, 2011. [doi:10.1371/journal.pone.0025507] Published online 7 November 2011. (online-only journal) *Mentor to T Yokoyama
Lu C, Stewart D, Lee JJ, Ji L, Ramesh R, Jayachandran G, Nunez M, Wistuba II, Erasmus JJ, Hicks ME, Grimm EA, Reuben J, Baladandayuthapani V, Templeton NS, McMannis JD, Roth JA. Phase I clinical trial of systemically administered TUSC2 (FUS1)- nanoparticles mediating functional gene transfer in humans. PLoS One. 2012;7(4):e34833. Epub 2012 Apr 25.
Neves LF, Krais JJ, Van Rite BD, Ramesh R, Resasco DE, Harrison RG: Targeting single-walled carbon nanotubes for the treatment of breast cancer using photothermal therapy. Nanotechnology. 20 Sept 2013;24(37):375104. PMID:23975064
Babu A, Templeton AK, Munshi A, Ramesh R: Nanoparticle-based drug delivery for therapy of lung cancer: progress and challenges. [Review Article] J Nanomater. Volume 2013, Article ID: 863951, 11 pages, 2013. doi:10.1155/2013/863951. Journal not currently indexed for MedLine.
Munshi A, Ramesh R: Mitogen-activated protein kinases and their role in radiation response. Genes Cancer. Sept/Oct 2013;4(9-10):401-408. PMID:24349638
Neves LFF, Krais JJ, Van Rite BD, Ramesh R, Resasco DE, Harrison RG: Targeting single-walled carbon nanotubes for the treatment of breast cancer using photothermal therapy. Nanotechnology 20 Sept 2013;24(37), Article ID 375104. PMID:23975064
Panneerselvam, J, Munshi A, Ramesh R: Molecular signaling events modulated by interleukin (IL)-24 in exerting its anticancer activity in cancer cells. J Mol Signal 8:15. 2013 Dec 30. doi:10.1186/1750-2187-8-15. PMID:24377906
Babu A, Wang Q, Muralidharan R, Shanker M, Munshi A, Ramesh R: Chitosan coated poly(lactic acid) polymeric nanoparticle-mediated combinatorial delivery of cisplatin and siRNA/plasmid DNA chemosensitizes cisplatin-resistant human ovarian cancer cells. Mol Pharm. 4 Aug 2014;11(8): 2720-2733, 2014; PMID: 24922589. doi: 10.1021/mp500259e. Epub 2014 Jun 20.
Templeton AK, Miyamoto S, Babu A, Munshi A, Ramesh R: Cancer stem cells: progress and challenges in lung cancer [Review Article] Stem Cell Invest. 2014, 1:9 (15 April 2014). (Online-only journal)
Kuroda S, Tam J, Roth JA, Sokolov K, Ramesh R: EGFR-targeted plasmonic magnetic nanoparticles suppress lung tumor growth by abrogating G2/M cell-cycle arrest and inducing DNA damage. Int J Nanomedicine. 8 Aug 2014;9:3825-39. doi: 10.2147/IJN.S65990. eCollection 2014 PMID: 25143731.