Stephenson Cancer Center
Stanton L. Young Biomedical Research Center
Suite # 1403
University of Oklahoma Health Sciences Center
975 N.E., 10th Street
Oklahoma City, OK 73104
PHONE: 405-271-6101 Ext: 52501
Jim and Christy Everest Endowed Chair in Cancer Developmental Therapeutics
Professor of Pathology
Director, Experimental Therapeutics and Translational Cancer Medicine
Chair, Fellowship Training and Mentoring Program
Member, OU Cancer Institute
B.Sc. - Biology, Osmania University
Hyderabad, India, 1985
M.Sc - Microbiology
Hyderabad, India, 1987
Tamil Nadu, India, 1992
Ph.D. - Molecular Biology
All India Institute of Medical Sciences (AIIMS)
New Delhi, India, 1994
Tulane University Medical Center,
New Orleans, LA, 1997
Studies in my laboratory are mainly focused on novel gene-based therapeutics using viral and non-viral vectors with emphasis on translational cancer research. There are two major research areas that are actively being pursued in the laboratory. The first research area is the development and testing of non-viral and nanoparticle-based gene delivery for cancer treatment, and the second research area is studying the antitumor and anti-angiogenic properties of IL-24. Our findings have lead to Phase I clinical trials for treatment of solid tumors.
Memberships & Certifications
Member, American Association for Cancer Research (AACR), 1994-present
Member, American Society of Cell and Gene Therapy (ASCGT), 1995-present
Member, American Society of Clinical Oncology (ASCO), 2007, present
NCI Career Development study section member, 2006-present
Co-Chair, Suicide gene therapy and apoptosis section, American Society of Cell and Gene Therapy (ASCGT), 2008
Panneerselvam, J, Munshi A, Ramesh R: Molecular signaling events modulated by interleukin (IL)-24 in exerting its anticancer activity in cancer cells. J Mol Signal 8:15. 2013 Dec 30. doi:10.1186/1750-2187-8-15. PMID:24377906
Babu A, Wang Q, Muralidharan R, Shanker M, Munshi A, Ramesh R: Chitosan coated poly(lactic acid) polymeric nanoparticle-mediated combinatorial delivery of cisplatin and siRNA/plasmid DNA chemosensitizes cisplatin-resistant human ovarian cancer cells. Mol Pharm. 4 Aug 2014;11(8): 2720-2733, 2014; PMID: 24922589. doi: 10.1021/mp500259e. Epub 2014 Jun 20.
Templeton AK, Miyamoto S, Babu A, Munshi A, Ramesh R: Cancer stem cells: progress and challenges in lung cancer [Review Article] Stem Cell Invest. 2014, 1:9 (15 April 2014). (Online-only journal)
Kuroda S, Tam J, Roth JA, Sokolov K, Ramesh R: EGFR-targeted plasmonic magnetic nanoparticles suppress lung tumor growth by abrogating G2/M cell-cycle arrest and inducing DNA damage. Int J Nanomedicine. 8 Aug 2014;9:3825-39. doi: 10.2147/IJN.S65990. eCollection 2014 PMID: 25143731.
Babu A, Amreddy N, Ramesh R. Nanoparticle-based cisplatin therapy for cancer.
Ther Deliv. 2015 Feb;6(2):115-9. doi: 10.4155/tde.14.109. PMID:
Panneerselvam J, Jin J, Shanker M, Lauderdale J, Bates J, Wang Q, Zhao YD, Archibald SJ, Hubin TJ,
Ramesh R. IL-24 Inhibits lung cancer cell migration and invasion by disrupting the SDF-1/CXCR4 signaling axis.
PLoS One. 2015 Mar 16;10(3):e0122439. doi: 10.1371/journal.pone.0122439. eCollection 2015. PMID:25775124
Srivastava A, Filant J, Moxley KM, Sood A, McMeekin S, Ramesh R. Exosomes: A role for naturally occurring nanovesicles in cancer growth, diagnosis and treatment.
Curr Gene Ther. Epub ahead of print 2014 Dec 23. doi: 10.2174/1566523214666141224100612. PMID:
25537774. (Print issue: 2015, Vol 15.)
Panneerselvam J, Shanker M, Jin J, Branch CD, Muralidharan R, Zhao DY, Chada S, Munshi A, Ramesh R. Phosphorylation of interleukin (IL)-24 is required for its anticancer activity. Oncotarget. 2015 May 18;6(18):16271-16286. PMID:
Ha JH, Gomathinayagam R, Yan M, Jayaraman M, Ramesh R, Dhanasekaran DN. Determinant role for the gep oncogenes, Gα12/13, in ovarian cancer cell proliferation and xenograft tumor growth. Genes Cancer. 2015; Advance Publication, 2015 Aug 3.
Al Mubarak ZH, Ramesh R, Liu L, Krishnan S. Surface plasmon resonance imaging of gold-small molecule interactions is influenced by refractive index and chemical structures.
J Colloid Interface Sci. Epub ahead of print 25 Aug 2015;460:209-213. doi: 10.1016/j.jcis.2015.08.059.