Recent Publications of the Department


Human GGT2 Does Not Autocleave into a Functional Enzyme: A cautionary tale for interpretation of microarray data on redox signaling.

West MB, Wickham S, Parks EE, Sherry DM, Hanigan MH. Antioxid Redox Signal. 2013 May 18. [Epub ahead of print] PMID: 23682772


Overexpression of Retinal Degeneration Slow (RDS) Protein Adversely Affects Rods in the rd7 Model of Enhanced S-Cone Syndrome.

Chakraborty D, Conley SM, Naash MI. PLoS One. 2013 May 1;8(5):e63321. doi: 10.1371/journal.pone.0063321.Print 2013. PMID: 23650562


KDM4/JMJD2 Histone Demethylases: Epigenetic Regulators in Cancer Cells.

Berry WL, Janknecht R. Cancer Res. 2013 May 15;73(10):2936-42. doi: 10.1158/0008-5472.CAN-12-4300. Epub 2013 May 3. PMID: 23644528


Bone marrow endothelial progenitors in atherosclerotic plaque resolution.

Yao L, Heuser-Baker J, Herlea-Pana O, Barlic-Dicen J. Organogenesis. 2013 Jan 1;9(1). [Epub ahead of print] PMID: 23538778


The choroid as a sclera growth regulator.

Summers JA. Exp Eye Res. 2013 Mar 23. doi:pii: S0014-4835(13)00062-6. 10.1016/j.exer.2013.03.008. PMID: 23528534


Deciphering mutant ELOVL4 activity in autosomal-dominant Stargardt macular dystrophy.

Logan S, Agbaga MP, Chan MD, Kabir N, Mandal NA, Brush RS, Anderson RE. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5446-51. doi: 10.1073/pnas.1217251110. Epub 2013 Mar 18. PMID: 23509295


LPA Stimulates the Phosphorylation of p130Cas via Gαi2 in Ovarian Cancer Cells.

Ward JD, Dhanasekaran DN. Genes Cancer. 2012 Sep;3(9-10):578-91. doi: 10.1177/1947601913475360. PMID: 23486563


DNA binding by the ribosomal DNA transcription factor rrn3 is essential for ribosomal DNA transcription.

Stepanchick A, Zhi H, Cavanaugh AH, Rothblum K, Schneider DA, Rothblum LI. J Biol Chem. 2013 Mar 29;288(13):9135-44. doi: 10.1074/jbc.M112.444265. Epub 2013 Feb 7. PMID: 23393135


Mps1 and Ipl1/Aurora B act sequentially to correctly orient chromosomes on the meiotic spindle of budding yeast.

Meyer RE, Kim S, Obeso D, Straight PD, Winey M, Dawson DS. Science. 2013 Mar 1;339(6123):1071-4. doi: 10.1126/science.1232518. Epub 2013 Jan 31. PMID: 23371552


Medaka fish, Oryzias latipes, as a model for human obesity-related glomerulopathy.

Ichimura K, Kawashima Y, Nakamura T, Powell R, Hidoh Y, Terai S, Sakaida I, Kodera Y, Tsuji T, Ma JX, Sakai T, Matsumoto H, Obara T. Biochem Biophys Res Commun. 2013 Feb 22;431(4):712-7. doi: 10.1016/j.bbrc.2013.01.053. Epub 2013 Jan 23. PMID: 23353086


Dysregulation of RNA polymerase I transcription during disease.

Hannan KM, Sanij E, Rothblum LI, Hannan RD, Pearson RB. Biochim Biophys Acta. 2013 Mar-Apr;1829(3-4):342-60. doi: 10.1016/j.bbagrm.2012.10.014. Epub 2012 Nov 12. PMID: 23153826


S/MAR-containing DNA nanoparticles promote persistent RPE gene expression and improvement in RPE65-associated LCA.

Koirala A, Makkia RS, Conley SM, Cooper MJ, Naash MI. Hum Mol Genet. 2013 Apr 15;22(8):1632-42. doi: 10.1093/hmg/ddt013. Epub 2013 Jan 18. PMID: 23335596


Developmental localization of nephrin in zebrafish and medaka pronephric glomerulus.

Ichimura K, Fukuyo Y, Nakamura T, Powell R, Sakai T, Janknecht R, Obara T. J Histochem Cytochem. 2013 Apr;61(4):313-24. doi: 10.1369/0022155413477115. Epub 2013 Jan 15. PMID: 23324868

Inhibition of human γ-glutamyl transpeptidase: development of more potent, physiologically relevant, uncompetitive inhibitors.

Wickham S, Regan N, West MB, Thai J, Cook PF, Terzyan SS, Li PK, Hanigan MH. Biochem J. 2013 Mar 15;450(3):547-57. doi: 10.1042/BJ20121435. PMID: 23301618


Role of melatonin and its receptors in the vertebrate retina.

Wiechmann AF, Sherry DM. Int Rev Cell Mol Biol. 2013;300:211-42. doi: 10.1016/B978-0-12-405210-9.00006-0. PMID: 23273863


Comparative analysis of DNA nanoparticles and AAVs for ocular gene delivery.

Han Z, Conley SM, Makkia R, Guo J, Cooper MJ, Naash MI. PLoS One. 2012;7(12):e52189. doi: 10.1371/journal.pone.0052189. Epub 2012 Dec 18. PMID: 23272225


Whole animal knockout of smooth muscle alpha-actin does not alter excisional wound healing or the fibroblast-to-myofibroblast transition.

Tomasek JJ, Haaksma CJ, Schwartz RJ, Howard EW. Wound Repair Regen. 2013 Jan-Feb;21(1):166-76. doi: 10.1111/wrr.12001. Epub 2012 Dec 18. PMID: 23253249


Retinal angiogenesis in the Ins2(Akita) mouse model of diabetic retinopathy.

Han Z, Guo J, Conley SM, Naash MI. Invest Ophthalmol Vis Sci. 2013 Jan 17;54(1):574-84. doi: 10.1167/iovs.12-10959. PMID: 23221078


Wtip and Vangl2 are required for mitotic spindle orientation and cloaca morphogenesis.

Bubenshchikova E, Ichimura K, Fukuyo Y, Powell R, Hsu C, Morrical SO, Sedor JR, Sakai T, Obara T. Biol Open. 2012 Jun 15;1(6):588-96. doi: 10.1242/bio.20121016. Epub 2012 May 4. PMID: 23213452

Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling.

Pasula S, Cai X, Dong Y, Messa M, McManus J, Chang B, Liu X, Zhu H, Mansat RS, Yoon SJ, Hahn S, Keeling J, Saunders D, Ko G, Knight J, Newton G, Luscinskas F, Sun X, Towner R, Lupu F, Xia L, Cremona O, De Camilli P, Min W, Chen H. J Clin Invest. 2012 Dec 3;122(12):4424-38. doi: 10.1172/JCI64537. Epub 2012 Nov 26. PMID: 23187125


Structural characterization of the second intra-discal loop of the photoreceptor tetraspanin RDS.

Chakraborty D, Rodgers KK, Conley SM, Naash MI. FEBS J. 2013 Jan;280(1):127-38. doi: 10.1111/febs.12055. Epub 2012 Nov 22. PMID: 23121719


Bone marrow endothelial progenitors augment atherosclerotic plaque regression in a mouse model of plasma lipid lowering.

Yao L, Heuser-Baker J, Herlea-Pana O, Iida R, Wang Q, Zou MH, Barlic-Dicen J. Stem Cells. 2012 Dec;30(12):2720-31. doi: 10.1002/stem.1256. PMID: 23081735


ETS variant 1 regulates matrix metalloproteinase-7 transcription in LNCaP prostate cancer cells.

Shin S, Oh S, An S, Janknecht R. Oncol Rep. 2013 Jan;29(1):306-14. Doi 10.3892/or.2012.2079. Epub 2012 Oct 16. PMID: 23076342

A comparative analysis of glomerulus development in the pronephros of medaka and zebrafish.

Ichimura K, Bubenshchikova E, Powell R, Fukuyo Y, Nakamura T, Tran U, Oda S, Tanaka M, Wessely O, Kurihara H, Sakai T, Obara T. PLoS One. 2012;7(9):e45286. doi: 10.1371/journal.pone.0045286. Epub 2012 Sep 18. PMID: 23028906


Structural disorganization of pronephric glomerulus in zebrafish mpp5a/nagie oko mutant.

Ichimura K, Fukuyo Y, Nakamura T, Powell R, Sakai T, Obara T. Dev Dyn. 2012 Dec;241(12):1922-32. doi: 10.1002/dvdy.23877. Epub 2012 Oct 25. PMID: 23027442


Oncogenic features of the JMJD2A histone demethylase in breast cancer.

Berry WL, Shin S, Lightfoot SA, Janknecht R. Int J Oncol. 2012 Nov;41(5):1701-6. doi: 10.3892/ijo.2012.1618. Epub 2012 Sep 4. PMID: 22948256

Cohesin acetylation promotes sister chromatid cohesion only in association with the replication machinery.

Song J, Lafont A, Chen J, Wu FM, Shirahige K, Rankin S. J Biol Chem. 2012 Oct 5;287(41):34325-36. doi: 10.1074/jbc.M112.400192. Epub 2012 Aug 15. PMID: 22896698


Therapeutic potential of a monoclonal antibody blocking the Wnt pathway in diabetic retinopathy.

Lee K, Hu Y, Ding L, Chen Y, Takahashi Y, Mott R, Ma JX. Diabetes. 2012 Nov;61(11):2948-57. doi: 10.2337/db11-0300. Epub 2012 Aug 13. PMID: 22891217


DNA nanoparticle-mediated ABCA4 delivery rescues Stargardt dystrophy in mice.

Han Z, Conley SM, Makkia RS, Cooper MJ, Naash MI. J Clin Invest. 2012 Sep 4;122(9):3221-6. doi: 10.1172/JCI64833. Epub 2012 Aug 13. PMID: 22886305


Characterization of the interactions of mammalian RNA polymerase I associated proteins PAF53 and PAF49.

Penrod Y, Rothblum K, Rothblum LI. Biochemistry. 2012 Aug 21;51(33):6519-26. doi: 10.1021/bi300408q. Epub 2012 Aug 8. PMID: 22849406

Differential developmental deficits in retinal function in the absence of either protein tyrosine sulfotransferase-1 or -2.

Sherry DM, Kanan Y, Hamilton R, Hoffhines A, Arbogast KL, Fliesler SJ, Naash MI, Moore KL, Al-Ubaidi MR. PLoS One. 2012;7(6):e39702. doi: 10.1371/journal.pone.0039702. Epub 2012 Jun 22. PMID: 22745813


Pattern of expression of p53, its family members, and regulators during early ocular development and in the post-mitotic retina.

Vuong L, Brobst DE, Saadi A, Ivanovic I, Al-Ubaidi MR. Invest Ophthalmol Vis Sci. 2012 Jul 20;53(8):4821-31. doi: 10.1167/iovs.11-8681. PMID: 22714890


Meiotic chromosome pairing is promoted by telomere-led chromosome movements independent of bouquet formation.

Lee CY, Conrad MN, Dresser ME. PLoS Genet. 2012;8(5):e1002730.doi: 10.1371/journal.pgen.1002730. Epub 2012 May 24. PMID: 22654677

Great expectations--or how to focus on prevention for all.

O'Donoghue DL. JAAPA. 2012 Mar;25(3):12. No abstract available. PMID: 22514951


Endoplasmic reticulum stress-associated cone photoreceptor degeneration in cyclic nucleotide-gated channel deficiency.

Thapa A, Morris L, Xu J, Ma H, Michalakis S, Biel M, Ding XQ. J Biol Chem. 2012 May 25;287(22):18018-29. doi: 10.1074/jbc.M112.342220. Epub 2012 Apr 9. PMID: 22493484


MMP-2 expression by fibroblasts is suppressed by the myofibroblast phenotype.

Howard EW, Crider BJ, Updike DL, Bullen EC, Parks EE, Haaksma CJ, Sherry DM, Tomasek JJ. Exp Cell Res. 2012 Aug 1;318(13):1542-53. doi: 10.1016/j.yexcr.2012.03.007. Epub 2012 Mar 17. PMID: 22449415


Defects in the outer limiting membrane are associated with rosette development in the Nrl-/- retina.

Stuck MW, Conley SM, Naash MI. PLoS One. 2012;7(3):e32484. doi: 10.1371/journal.pone.0032484. Epub 2012 Mar 12. PMID: 22427845


Expression and role of p53 in the retina.

Vuong L, Conley SM, Al-Ubaidi MR. Invest Ophthalmol Vis Sci. 2012 Mar 15;53(3):1362-71. doi: 10.1167/iovs.11-8909. Review. PMID: 22427613

ETV1, 4 and 5: an oncogenic subfamily of ETS transcription factors.

Oh S, Shin S, Janknecht R. Biochim Biophys Acta. 2012 Aug;1826(1):1-12. doi: 10.1016/j.bbcan.2012.02.002. Epub 2012 Mar 8. Review. PMID: 22425584


Focus on molecules: sulfotyrosine.

Kanan Y, Hamilton RA, Sherry DM, Al-Ubaidi MR. Exp Eye Res. 2012 Dec;105:85-6. doi: 10.1016/j.exer.2012.02.014. Epub 2012 Mar 1. No abstract available. PMID: 22406006

Histone demethylase JMJD5 is essential for embryonic development.

Oh S, Janknecht R. Biochem Biophys Res Commun. 2012 Mar 30;420(1):61-5. doi: 10.1016/j.bbrc.2012.02.115. Epub 2012 Feb 28. PMID: 22402282





































































































































































































































































































































































































































































































































































































Biol Open. 2012 Jun 15;1(6):588-96. doi: 10.1242/bio.20121016. Epub 2012 May 4. Yao L, Heuser-Baker J, Herlea-Pana O, Iida R, Wang Q, Zou MH, Barlic-Dicen J.































































Biol Open. 2012 Jun 15;1(6):588-96. doi: 10.1242/bio.20121016. Epub 2012 May 4. Yao L, Heuser-Baker J, Herlea-Pana O, Iida R, Wang Q, Zou MH, Barlic-Dicen J.