Susannah Rankin

 

Assistant Member, Molecular, Cell and Developmental Biology Research Program, Oklahoma Medical Research Foundation

Adjunct Assistant Professor, Department of Cell Biology

EDUCATION

B.A., Reed College, Portland, Oregon
Ph.D., Tufts University School of Medicine, Boston, Massachusetts


RESEARCH SUMMARY

I am interested in sister chromatid cohesion and how cell cycle progression coordinates this process. Though first observed and appreciated many decades ago, the mechanism of sister chromatid cohesion remains poorly understood. The study of chromatid cohesion has been hampered by several factors: features buried in the complexity of chromatin structure, inadequate assays, redundant mechanisms, and a lack of sequence conservation among species.

We recently discovered a cell cycle-regulated protein, sororin, that is required for sister chromatid cohesion in vertebrates. In my laboratory we are investigating the mechanism of action of sororin and how it functions in the context of other known cohesion factors and activities. We are also pursuing a broad-based inquiry into sister chromatid cohesion and the effects of its failure on genome stability in higher eukaryotes.

SELECTED PUBLICATIONS

1. Rankin S, and MW Kirschner. Regulation of sister chromatid cohesion by sororin. Cell Cycle 4(8): 1039-1042, 2005.

2. Rankin S, Ayad N, and MW Kirschner. Sororin, a substrate of the anaphase promoting complex, is required for sister chromatid cohesion in vertebrates. Molecular Cell 18: 185-200, 2005.

3. Ayad NG, Rankin S, Ooi D, Rape M, and MW Kirschner. Identification of Ubiquitin Ligase Substrates by In Vitro Expression Cloning. Methods in Enzymology. 399: 404-414, 2005.

4. Campellone KG, Rankin S, Pawson T, Kirschner MW, Tipper DJ, and JM Leong. Clustering of Nck by a 12 residue Tir phosphopeptide is sufficient to trigger localized actin assembly. J. Cell Biology 164(3): 407-416, 2004.

5. Ayad NG, Rankin S, Murakami M, Jebanathirajah J, Gygi S, and MW Kirschner. Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC. Cell 113: 101-113, 2003.

6. Rankin S, Li Z, and RR Isberg. Macrophage-induced genes of Legionella pneumophila: protection from reactive intermediates and solute imbalance during intracellular growth. Infect Immun 70: 3637-48, 2002.


MAILING ADDRESS

Molecular, Cell and Developmental Biology Research Program, MS 48
Oklahoma Medical Research Foundation
825 N.E. 13th Street
Oklahoma City, Oklahoma 73126

Phone: (405) 271-8190
Fax: (405) 271-7312

 

Susannah-Rankin@omrf.org