David M. Sherry

 

Associate Professor, Department of Cell Biology

EDUCATION

B.S., Cell Biology, University of Kansas, Lawrence, Kansas
Ph.D., Neuroscience, University of Florida, Gainesville, Florida

RESEARCH SUMMARY

    A rapidly developing area of interest is cell migration and its regulation. We are pursuing studies of growth factors and other signals in regulating the transition of cells from differentiated, quiescent phenotypes to migratory phenotypes. In particular we are interested in the signals that regulate the acquisition of a polarized migratory phenotype and determine the mode of migration (e.g., coordinated migration by cell ensembles vs. individual cell migration; directed vs. random migration). These studies encompass reorganization of cytoskeleton and other intracellular components, navigation, adhesion, signaling, trafficking, and proliferation. Specific projects focus on the transition of vascular smooth muscle cells from a normally differentiated and quiescent phenotype to a migratory phenotype, such as occurs during normal or pathological angiogenesis.

      A second, long-standing area of interest in the lab is anatomical and synaptic architecture in the central nervous system. These studies investigate the exquisite organization and specificity of connections between nerve cells, how this architecture develops and is affected by insult, and its capacity for repair. Most of our previous work has utilized the retina as a model system, but other areas of the central nervous system are also of interest.

    Technical approaches employed in the lab integrate anatomical, pharmacological and molecular methods to manipulate and visualize signaling processes, cytoskeletal dynamics and cell behavior.  Approaches include shRNA and pharmacological treatments to manipulate expression or activity of specific proteins, expression of fluorescent reporters and biosensors, live cell imaging to directly visualize cellular behaviors, and immunolabeling at the light, confocal, and electron microscopic levels.

PUBLICATIONS

Wang MM, Janz R, Belizaire R, Frishman LJ, Sherry DM. 2003. Differential distribution and developmental expression of synaptic vesicle protein 2 isoforms in the mouse retina. J Comp Neurol. 460:106-122.

Sherry DM, Wang MM, Bates J, Frishman LJ. 2003. Expression of vesicular glutamate transporter 1 in the mouse retina reveals temporal ordering in development of rod vs. cone and ON vs. OFF circuits. J Comp Neurol. 465:480-498.

Sherry DM, Mitchell R, Standifer KM, du Plessis B. 2006. Distribution of plasma membrane-associated syntaxins 1 through 4 indicates distinct trafficking functions in the synaptic layers of the mouse retina. BMC Neurosci 7:54.   PMCID: PMC1555595

Phillips MJ, Otteson DC, Sherry DM. 2010. Progression of neuronal and synaptic remodeling in the rd10 mouse model of Retinitis pigmentosa. J. Comp Neurol. 518:2071-2089. PMCID: PMC2881548

Wan Q-F, Zhou Z-Y, Thakur P, Vila A, Sherry DM, Janz R, Heidelberger R. 2010. SV2 acts via presynaptic calcium to regulate neurotransmitter release. Neuron. 66:884-895. PMCID: PMC2913707

Sherry DM, Murray A, Hoffhines A, Kanan Y, Arbogast KL, Fleisler SJ, Burns ME, Moore KL, Al-Ubaidi MR. 2010. Lack of protein tyrosine sulfation disrupts photoreceptor outer segment morphogenesis, retinal function and retinal anatomy. Eur J Neurosci. 32:1461-1472. PMCID: PMC3058723

Rush JS, Quinalty LM, Engelman L, Sherry DM, Ceresa BP. 2012. Endosomal accumulation of the activated epidermal growth factor receptor (EGFR) induces apoptosis. J Biol Chem 287:712-722. PMCID: PMC3249126

Wiechmann AF, Sherry DM. 2012. Melatonin receptors are anatomically organized to modulate transmission specifically to cone pathways in the retina of Xenopus laevis. J Comp Neurol. 520:1115-1127. PMC Journal - In Process

Howard E, Crider BJ, Updike DL, Bullen EC, Parks EE, Haaksma CJ, Sherry DM, Tomasek JJ. 2012. MMP-2 expression by fibroblasts is suppressed by the myofibroblast phenotype. Exp Cell Res 18:1542-1553. PMC Journal - In Process

Sherry DM, Kanan Y, Hamilton R, Hoffhines A, Arbogast KL, Fliesler SJ, Naash MI, Moore KL, Al-Ubaidi MR. 2012. Differential developmental deficits in retinal function in the absence of either protein tyrosine sulfotransferase-1 or -2. PLoS One. 7:e39702.

Sherry DM, Blackburn BA. 2013. P-Rex2, a Rac-guanine nucleotide exchange factor, is expressed selectively in ribbon synaptic terminals of the mouse retina. BMC Neurosci. 14:70. PMC Journal - In Process

Wu F, Li R, Umino Y, Kaczynski TJ, Sapkota D, Li S, Xiang M, Fliesler SJ, Sherry DM, Gannon M, Solessio E, Mu X. 2013. Onecut1 is essential for horizontal cell genesis and retinal integrity. J Neurosci. 33:13053-13065. PMC Journal - In Process

 


 

MAILING ADDRESS

University of Oklahoma Health Sciences Center
Department of Cell Biology
P.O. Box 26901
Oklahoma City, OK 73126-0901
Phone: (405) 271-8001 ext. 45514
Fax: (405) 271-3548

David-Sherry@ouhsc.edu

David Sherry Interests
 
NIH Biosketch
 
Recent Publications

2010 Phillips_etal_JCompNeurol
2010 Sherry_etal_EurJNeurosci
2010 Wan_etal_Neuron

2011 Ivanovich etal IOVS
2011 Xu etal IOVS
 
2012 Howard etal ExpCellSci
2012 Kanan etal ExpEyeRes
2012 Rush etal JBC
2012 Wiechmann Sherry JCompNeurol
2012 Xu etal IOVS
2012 Sherryetal PLoSOne
2013 Sherry-Blackburn BMC Neurosci
2013 Vuong etal PLoSOne
2013 West etal ARS
2013 Wiechmann-Sherry IntRevCellMolBiol
2013 Wu etalJNeurosci