Ji Hee Ha

Assistant Professor of Research, Department of Cell Biology;

EDUCATION

Ph.D in Pharmacology, Hanyang University, Seoul, Korea
Postdoctoral Fellow Laboratory of Dr. Danny N. Dhanasekaran, and Dr. Premkumar Reddy Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, PA.

RESEARCH SUMMARY

Ovarian cancer has been identified as the fifth leading cause of cancer death in the United States and 52 % of patients die because of the aggressive growth of these cancers. It has been recently observed that the lipid growth factor lysophosphatidic acid (LPA) plays a major role in the genesis and progression ovarian cancer. While the primary mechanism(s) through which LPA promotes tumorigenesis and/or tumor progression has remained largely unknown, recent studies from several laboratories including ours have shown that LPA-mediated oncogenic signaling involves the gep oncogenes, Ga12 and Ga13. In this context our observations that LPA-LPAR-Ga12/13 mediated activation of JNK involves the scaffold protein JLP and Ga12/13 mediated oncogenic pathways involves JLP are highly significant. Therefore, elucidating the mechanism of interaction between the gep oncogenes, JLP, and the downstream signaling components can provide a clear understanding of their potential role in the oncogenic programs activated by these oncogenic G protein a- subunits. Such an understanding will be of critical importance in developing therapeutic targets for ovarian cancers in which the signaling by LPA-LPAR-Ga12/13 signaling nexus appears to play a determinant role.

RECENT PUBLICATIONS

 

Rashmi N. Kumar, Ji Hee Ha, Rangasudhagar Radhakrishnan, and Danny N. Dhanasekaran. Transactivation of platelet-derived growth factor receptor a by the GTPase-deficient activated mutant of Ga2.  Molecular and Cellular Biology 2006; Jan 50-62.

Radhika V, Proikas-Cezanne T, Jayaraman M, Onesime D, Ha JH, Dhanasekaran DN.  Chemical sensing of DNT by engineered olfactory yeast strain.  Nat Chem Biol. 2007 Jun; 3(6): 325-330.

Dhanasekaran DN, Radhika V, Proikas-Cezanne T, Jayaraman M, Ha J. Heterologous expression of olfactory receptors for targeted chemosensing.  Ann N Y Acad Sci. 2009 Jul; 1170:157-60.

Yang YM, Lee S, Nam CW, Ha JH, Jayaraman M, Dhanasekaran DN, Lee CH, Kwak MK, Kim SG.  G(alpha) 12/13 inhibition enhances the anticancer effect of bortezomib through PSMB5 downregulation.  Carcinogenesis. 2010 Jul: 31(7): 1230-7.

Jatiani SS. Cosenza SC, Reddy MV, Ji Hee Ha, Baker SJ, Samanta AK, Olnes MJ, Pfannes L, Sloand EM, Arlinghaus RB, Reddy EP.  A Non-ATP-Competitive Dual Inhibitor of JAK2V617F and BCR-ABLT315I Kinase Elucidation of a Novel Therapeutic Spectrum Based on Substrate Competitive Inhibition.  Genes Cancer. 2010 April; 1(4): 331-345.

Kim ES, Jeong JB, Kim S, Lee KM, Ko E, Noh DY, Hwang KT, Ha JH, Lee CH, Kim SG, Moon A. The G12 family proteins upregulate matrix metalloproteinase-2 via p53 leading to human breast cell invasion.  Breast Cancer Res. Treat. 2010 Nov; 124(1): 49-61.

Rangasudhagar Radhakrishnan, Ji Hee Ha, Danny Dhanasekaran.  Mitogenic signaling by the gep oncogene involves the upregulation of s-phase kinase-associated protein 2.  Genes Cancer 2010 Oct; 1(10): 1033-43.

Goldsmith ZG, Ha JH, Jayaraman M, Dhanasekaran DN. Lysophosphatidic Acid Stimulates the Proliferation of Ovarian Cancer Cells via the gep Proto-Oncogene Ga (12). Genes Cancer. 2011 May; 2(5): 563-75.

Jacob A. Gardner, Ji Hee Ha, Muralidharan Jayaraman, and Danny N. Dhanasekaran. The gep Proto-Oncogene Ga13 Mediates Lysophosphatidic Acid-Mediated Migration of Pancreatic Cancer Cells. Pancreas. 2013 Jul; 42(5): 819-28.

Ha JH, Ward JD, Varadarajalu L and Dhanasekaran DN. The gep proto-oncogene Gα12 mediates LPA-stimulated activation of CREB in ovarian cancer cells. Cell Signal. 2013 Sep 19.

  
 

MAILING ADDRESS

University of Oklahoma Health Sciences Center
BRC 1470
975 NE 10th Street
Oklahoma City, OK 73104
Phone: (405) 271-6540
Fax: (405) 271-6507

Ji-Hee-Ha@ouhsc.edu