Sook Shin

Assistant Professor of Research


EDUCATION

B.S. in Microbiology, Seoul National University, Korea
M.S. in Microbiology, Seoul National University, Korea
Ph.D. in Molecular Virology, Baylor College of Medicine, Houston, Texas

RESEARCH SUMMARY

JmjC domain-containing (JMJD) histone demethylases play multiple roles in epigenetics and are thus implicated in developmental processes, aging, DNA repair, stem cell biology and tumorigenesis. Our laboratory generated reagents for the majority of the 32 human JMJD family members and harnessed these tools to probe their interaction with numerous important downstream effectors of signaling pathways, including the estrogen and androgen receptors. In addition, we study selected JMJD proteins with the help of genetically engineered mice. Thereby, we explore the function and molecular mechanisms of JMJD proteins in various biological processes and diseases, especially cancer and metabolic disorders.

RECENT PUBLICATIONS

Shin, S., Kim, T.-D., Jin, F., van Deursen, J. M., Dehm, S. M., Tindall, D. J., Grande, J. P., Munz, J.-M., Vasmatzis, G., and Janknecht, R. (2009). Induction of prostatic intraepithelial neoplasia and modulation of androgen receptor by ETS variant 1/ETES-related protein 81. Cancer Res. 69, 8102-8110.

Kim, J., Shin, S., Subramaniam, M., Bruinsma, E., Kim, T.-D., Hawse, J. R., Spelsberg, T. C., and Janknecht, R. (2010). Histone demethylase JARID1B/KDM5B is a corepressor of TIEG1/KLF10. Biochem. Biophys. Res. Commun. 401, 412-416.

Kim, T.-D., Shin, S., Berry, W. L., Oh, S., Janknecht, R. (2012). The JMJD2A demethylase regulates apoptosis and proliferation in colon cancer cells. J. Cell. Biochem. 113, 1368-1376.

Oh, S., Shin, S., Janknecht, R. (2012). ETV1, 4 and 5: An oncogenic subfamily of ETS transcription factors. Biochim. Biophys. Acta 1826, 1-12.

Kim, T.-D., Oh, S., Shin, S., Janknecht, R. (2012). Regulation of tumor suppressor p53 and HCT116 cell physiology by histone demethylase JMJD2D/KDM4D. PLoS One 7, e34618.

DiTacchio, L., Bowles, J., Shin, S., Lim, D.-S., Koopman, P., Janknecht, R. (2012). Transcription factors ER71/ETV2 and SOX9 participate in a positive feedback loop in fetal and adult mouse testis. J. Biol. Chem. 287, 23657-23666.

Berry, W. L., Shin, S., Lightfoot, S. A., Janknecht, R. (2012). Oncogenic features of the JMJD2A histone demethylase in breast cancer. Int. J. Oncol. 41, 1701-1706

Shin, S., Oh, S., An, S., Janknecht, R. (2013). ETS variant 1 regulates matrix metalloproteinase-7 transcription in LNCaP prostate cancer cells. Oncol. Rep. 29, 306-314.

Oh, S., Shin, S., Lightfoot, S. A., Janknecht, R. (2013). 14-3-3 proteins modulate the ETS transcription factor ETV1 in prostate cancer. Cancer Res. 73, 5110-5119.

Kim, T.-D., Jin, F., Shin, S., Oh, S., Lightfoot, S. A., Grande, J. P., Johnson, A. J., van Deursen, J. M., Wren, J. D., Janknecht, R. (2016). Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1. J. Clin. Invest. 126, 706-720.

Kim, T.-D., Shin, S., Janknecht, R. (2016). ETS transcription factor ERG cooperates with histone demethylase KDM4A. Oncol. Rep. 35, 3679-3688.

Kim, T.-D., Oh, S., Lightfoot, S. A., Shin, S., Wren, J. D., Janknecht, R. (2016). Upregulation of PSMD10 caused by the JMJD2A histone demethylase. Int. J. Clin. Exp. Med. 9, 10123-10134.



MAILING ADDRESS

University of Oklahoma Health Science Center
Biomedical Research Center 1464
975 NE 10th Street
Oklahoma City, OK 73104, USA
Phone: (405) 271-8001 X 47419
Fax: (405) 271-3548

sshin2@ouhsc.edu