Ping Song, PhD

Assistant Professor
Mailing Address:
941 Stanton L. Young Blvd., BSEB 312 
Oklahoma City, OK 73104
Telephone: (405) 271-8001 ext 48691 
Fax: (405) 271-3973 
Email: ping-song@ouhsc.edu

Research Interests

Vascular remodeling in Diabetes/obesity
Diabetic patients experience higher incidence of restenosis after percutaneous coronary intervention (PCI), and lower efficacy of drug-eluting stenting (DES). Emerging evidences indicate that the hyperinsulinemia featured in obesity/insulin-resistance and type 2 diabetes is the key risk factor for the elevated restenosis. However, pathological mechanisms responsible for the unique vascular response to endothelial denudation injury in diabetes remain largely unknown. Ongoing studies in our laboratory seek to understand if and how diabetes/obesity alters AMP-activated protein kinase (AMPK) signaling cascades, and if the modulation of AMPK would bring translational outcomes in this disease via regulating genomic stability and vascular smooth muscle cell (VSMC) differentiation, proliferation, and migration. In addition, we are also interested in cellular or metabolic plasticity/reprogramming and in their epigenetic regulation and pathophysiological function in both vascular regenerative medicine and vascular remodeling of diabetes/obesity.

Education

  • 2000 - PhD - Nanjing Agricultural University, Nanjing, China
  • 1993 - MS - Yangzhou University, Yangzhou, China
  • 1990 - BA - Jiangsu Agricultural University, Yangzhou, China

Recent Pubilcations

1. Song P, and Zou M-H. (2012)  Regulation of NAD(P)H oxidases by AMPK in cardiovascular systems. Free Radical Biology and Medicine. doi: 10.1016/j.freeradbiomed.2012.01.025

2. Wang S, Song P, and Zou M-H. (2012) AMP-activated protein kinase, stress responses and cardiovascular diseases. Clinical Science, 122: 555-573

3. Wu Y, Dong Y, Song P, Zou M-H. (2012) Activation of the AMP-Activated protein kinase (AMPK) by nitrated lipids in endothelial cells. PLoS ONE 7(2): e31056. doi:10.1371/journal.pone.0031056

4. Wang S, Song P, and Zou M-H. (2012) Inhibition of AMP-activated protein kinase α (AMPKα) by doxorubicin accentuates genotoxic stress and cell death in mouse embryonic fibroblasts and cardiomyocytes: role of p53 and SIRT1. The Journal of Biological Chemistry, 287(11): 8001-8012

5. Song P*, Wang S, He C-Y, Wang S, Liang B, Viollet B, and Zou M-H*. (2011) AMPKα2 deletion exacerbates neointima formation by upregulating Skp2 in vascular smooth muscle cells. Circulation Research. 109: 1230-1239. (*Corresponding authors)

6. Xu MJ*, Song P*, Shirwany N , Liang B , Xing J, Viollet B , Wang X, Zhu Y , Zou M-H. (2011)  Impaired expression of uncoupling protein 2 causes defective postischemic angiogenesis in mice deficient in AMP-activated protein kinase α subunits. Arterioscler Thromb Vasc Biol. 31:1757-1765. (*Joint first authors)

7. Zhang M, Song P, Xu J, Zou M-H. (2011) Activation of NAD(P)H oxidase by thromboxane A2 receptor uncouples endothelial nitric oxide synthase. Arterioscler Thromb Vasc Biol. 31: 125-132

8. Han Y, Wang Q, Song P, Zhu Y, Zou M-H. (2010) Redox regulation of the AMP-activated protein kinase. PLoS ONE, 5: e15420

9. Wang S, Dale GL, Song P, and Zou M-H. (2010) AMPKα 1 deletion shortens erythrocyte life span in mice: role of oxidative stress. The Journal of Biological Chemistry, 285(26): 19976-19985

10. Xu J, Wang S, Wu Y, Song P, and Zou M-H. (2009) Tyrosine Nitration of PA700 Activates the 26S Proteasome to Induce Endothelial Dysfunction in Mice with Angiotensin II-induced Hypertension. Hypertension, 54: 625-632

11. Dong Y, Wu Y, Wu M, Wang S, Zhang J, Xie Z, Xu J, Song P, Wilson K, Zhao Z, Lyons T, and Zou M-H. (2009) Activation of Protease Calpain by Oxidized and Glycated LDL Increases the Degradation of Endothelial Nitric Oxide Synthase. Journal of  Cellular and Molecular Medicine, 13(9a): 2899-2910

12. Wang S, Xu J, Song P, Viollet B, and Zou M-H. (2009) In Vivo Activation of AMP-activated Protein Kinase Attenuates Diabetes-enhanced Degradation of GTP Cyclohydrolase I. Diabetes, 58: 1893-1901

13. Song P, Zhang M, Wang S, Xu J, Choi H C, and Zou M-H. (2009) Thromboxane A2 Receptor Activates a Rho-associated Kinase/LKB1/PTEN Pathway to Attenuates Endothelium Insulin Signaling. The Journal of Biological Chemistry, 284(25): 17120-17128

14. Wang S, Xu J, Song P, Wu Y, Zhang J, Choi H C, and Zou M-H. (2008) Acute Inhibition of Guanosine Triphosphate Cyclohydrolase 1 Uncouples Endothelial Nitric Oxide Synthase and Elevates Blood Pressure. Hypertension, 52:484-490

15. Choi H C, Song P, Xie Z, Wu Y, Xu J, Zhang M, Dong Y, Wang S, Lau K, and Zou M-H. (2008) Reactive Nitrogen Species Is Required for the Activation of the AMP-activated Protein Kinase by Statin in Vivo. The Journal of Biological Chemistry, 283 (29): 20186-20197

16. Song P, Xie Z, Wu Y, Xu J, Dong Y, and Zou M-H. (2008) Protein Kinase C ζ-dependent LKB1 Serine 428 Phosphorylation Increases LKB1 Nucleus Export and Apoptosis in Endothelial Cells. The Journal of Biological Chemistry, 283(18): 12446-12455

17. Zhang M, Dong Y, Xu J, Xie Z, Wu Y, Song P,  Guzman M, Wu J, and Zou M-H. (2008) Thromboxane Receptor Activates the AMP-Activated Protein Kinase in Vascular Smooth Muscle Cells via Hydrogen Peroxide. Circulation Research, 102(3): 328-337

18. Song P, Wu Y, Xu J, Xie Z, Dong Y, Zhang M, and Zou M-H. (2007) Reactive Nitrogen Species Induced by Hyperglycemia Suppresses Akt Signaling and Triggers Apoptosis by Upregulating Phosphatase PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) in an LKB1-Dependent Manner. Circulation, 116(14): 1585-1595

19. An Z *, Wang H *, Song P *, Zhang M, Geng X, and Zou M-H. (2007)  Nicotine-induced Activation of AMP-activated Protein Kinase Inhibits Fatty Acid Synthase in 3T3L1 Adipocytes: A Role for Oxidant Stress. The Journal of Biological Chemistry, 282(37): 26793-26801. (*Joint first authors)

20. Xu J, Wu Y, Song P, Zhang M, Wang S, and Zou M-H. (2007) Proteasome-dependent Degradation of Guanosine 5’-Triphosphate Cyclohydrolase I Causes Tetrahydrobiopterin Deficiency in Diabetes Mellitus. Circulation, 116(8):944-953

21. Wu Y, Song P, Xu J, Zhang M, and Zou M-H. (2007) Activation of Protein Phosphatase 2A by Palmitate Inhibits AMP-activated Protein Kinase. The Journal of Biological Chemistry, 282(13): 9777-9788.

22. Song P, Wei J-X, and Wang H-C R. (2005) Distinct roles of the ERK pathway in modulating apoptosis of Ras-transformed and non-transformed cells induced by anticancer agent FR901228. Federation of European Biochemical Societies Letters, 579(1): 90-94

23. Song P, Wei J-X, Plummer III H, and Wang H-C R. (2004) Potentiated caspase-3 in Ras-transformed 10T1/2 cells. Biochemical and Biophysical Research Communications, 322(2): 557-564

24. Song P, and Wang H-Cn R. (2004) Efficient identification of tetR-expressing cell lines for tetracycline-regulated gene expression. Electronic Journal of Biotechnology. 7(2): 210-213

25. Mei J, Hu H, McEntee M, Plummer III H, Song P, and Wang H-C R. (2003) Transformation of non-cancerous human breast epithelial cell line MCF10A by the tobacco-specific carcinogen NNK. Breast Cancer Research and Treatment, 79: 95-105

26. Wu Y, Zhang C, Dong Y, Wang S, Song P, Viollet B, Zou M-H. (2012)  Activation of the AMP-activated protein kinase by eicosapentaenoic acid (EPA, 20:5 n-3) improves endothelial function in vivo. PLoS ONE 7(4): e35508. doi:10.1371/journal.pone.0035508

27. Liu X, Song P. (2013) Is the association of diabetes with uncontrolled blood pressure stronger in Mexican Americans and Blacks than in Whites among diagnosed hypertensive patients?  American Journal of Hypertension, doi: 10.1093/ajh/hpt109

28. Zhang W, Wang Q, Song P, Zou M-H. (2013) Liver kinase B1 is required for white adipose tissue growth and differentiation. Diabetes, 62(7): 2347-2358.

Book Chapters

1. Song P. (2010) Brassinosteroid. In: Newly Discovered Plant Hormones, Xie Zhou (ed), Science and Technology Press of Jiangsu, Nanjing, Jiangsu, China. pp 10-86

Current Lab Members

Hairong Xu, PhD

Yue Wu, PhD

Former Lab Members

Yanhong Zhou, PhD

Qiongxin Wang, PhD Candidate

Dai Nguyen, Undergraduate Student