Publications

Okon, I.S., Coughlan, K.A., Zhang, C., Moriasi, C., Ding, Ye., Song, P., Zhang, W., Li, G., Zou, M.H. Promotion of Rab7-mediated lysosome-dependent neuropilin-1 degradation by LKB1 inhibits angiogenesis in vivo. Journal of Clinical Investigation. In Press.

Wang, Q., Xie, Z., Zhang, W., Zhou, J., Wu, Y., Zhang, M., Zhu, H., Zou, M.H. Myeloperoxidase deletion prevents high-fat diet-induced obesity and insulin resistance. Diabetes. In Press.

Li, H., Min, Q., Ouyang, C., Lee, Y., He, C., Zou, M.H., Xie, Z. AMPK Activation Prevents Excess Nutrient-induced Hepatic Lipid Accumulation by Inhibiting mTORC1 Signaling and Endoplasmic Reticulum Stress Response. BBA - Molecular basis of Disease.  In Press.

Song, P. and Zou, M.H. Redox regulation of endothelial cell fate.  Cell Mol Life Sci. In Press.

Wang, Q., Zhang, M., Ding, Y., Wang, Q., Zhang, W., Song, P., Zou, M.H. Activation of NAD(P)H Oxidase by tryptophan-derived 3-hydroxykynurenine Accelerates Endothelial Apoptosis and Dysfunction In Vivo. Circulation Research, 114:480-492, 2014.  PMCID: In Process

Okon, I., Coughlan, AK., Zou, M.H. Liver Kinase B1 Expression Promotes Phosphatase Activity and Abrogation of Receptor Tyrosine Kinase Phosphorylation in Human Cancer Cell Lines. J. Biol. Chem. 289(3):1639-48, 2014.  PMCID: PMC3894343

Li, H., Lee, J., He, C., Zou, M.H., and Xie, Z. by Suppression of mTORC1/STAT3/Notch1 pathway by activated AMPK prevents hepatic insulin resistance induced excess amino acids. AJP-Endocrinology and Metabolism. 306(2):E197-209, 2014.  PMCID: PMC3920006
 
Shirwany, N. A., Zou, M. H. AMPK: A cellular metabolic and redox sensor. A minireview. Front Biosci (Landmark Ed). 19:447-74, 2014.  PMCID: 24389195 

Zhang, W., Wang, Q., Wu, Y., Moriasi, C., Liu, Z., Dai, X., Wang, Q., Liu, W., Yuan, Z.Y. Zou, M.H. Endothelial cell-specific LKB1 deletion causes endothelial dysfunction and hypertension in mice in vivo. Circulation. 129(13):1428-39, 2014. PMCID3894343 

Zhu, H., Foretz, M., Xie, Z., Zhang, M., Xing, J., Leclerc, J., Gaudry, M., Viollet, B., Zou, M.H. AMPKα1 is required for autophagy-dependent mitochondrial clearance during erythrocyte maturation. Autophagy. 10:9, 1-13, 2014.

Zhang, W., Wang, Q., Song P., Zou, M.H.  Liver Kinase B1 Is Required for White Adipose Tissue Growth and Differentiation.  Diabetes.  62(7):2347-58, 2013.  PMCID: PMC3712073 

Zhu H, Moriasi CM, Zhang M, Zhao Y, Zou MH.  Phosphorylation of Serine 399 in LKB1 Short Form by Protein Kinase Cζ is required for its Nucleocytoplasmic Transport and Consequent AMPK Activation.  J. Biol. Chem.  288(23):16495-505, 2013.  PMCID: PMC3675585

Song, Y., Li, X., Wang, D., Fu, C., Zhu, Z., Zou, M.H. (co-corresponding author), Zhu, Y. Transcription factor Krüppel-like factor 2 plays a vital role in endothelial colony forming cells differentiation. Cardiovascular Research. 99(3):514-24, 2013.  PMCID: PMC3841418
 
Zhao, Y., Wu, J., Zhu, H., Song, P., Zou, M.H.  Peroxynitrite-dependent Zinc Release and Inactivation of Guanosine 5'-triphosphate Cyclohydrolase 1 instigates its Ubiquitination in Diabetes.  Diabetes.  62(12):4247-56, 2013.  PMCID: PMC3837037

Song, P., Zhou, Y., Coughlan, K.C., Dai, X., Xu, H., Viollet, B., Zou, M.H.  Adenosine monophosphate-activated protein kinase-α2 deficiency promotes vascular smooth muscle cell migration via S-phase kinase-associated protein 2 upregulation and E-cadherin downregulation.  Arterioscler. Thromb. Vasc. Biol. 33(12):2800-9, 2013.  PMCID: PMC3910301

Zou, M.H. and Xie, Z.  Regulation of interplay between autophagy and apoptosis in the diabetic heart: New role of AMPK.  Autophagy. 9(4)624-5, 2013.  PMCID: PMC3627682

He, J., Zhou, Y., Xing, X., Wang, Q., Zhu, H., Zhu, Y., Zou, M.H.  Liver kinase B1 is required for thromboxane receptor-dependent NF-κB activation and inflammatory responses.  ATVB 33(6):1297-305, 2013.  PMCID: PMC3868917

Liu, C., Wu, J. L., and Zou, M.H. Activation of AMP-activated protein kinase alleviates high glucose-induced dysfunction of brain endothelial cell tight junction dynamics. Free Radical Biol. & Med. 14;53(6):1213-1221, 2012.  PMCID: PMC3437014

Zhao, Y., Zhu, H., Zou, M.H. Non-Covalent Interaction between Polyubiquitin and GTP Cyclohydrolase 1 Dictates Its Degradation. PLoS One. 7(9):e43306, 2012.  PMCID: PMC3440371

He, C., Zhu, H., Li, H, Zou, M. H. (Corresponding authors) and Xie, Z. Dissociation of Bcl-2–Beclin1 Complex by Activated AMPK Enhances Cardiac Autophagy and Protects Against Cardiomyocyte Apoptosis in Diabetes. Diabetes.  62(4):1270-81, 2013.  PMCID: PMC3609561

Yao L, Heuser-Baker J, Herlea-Pana O, Iida R, Wang Q, Zou M. H. Barlic-Dicen J. Bone Marrow Endothelial Progenitors Augment Atherosclerotic Plaque Regression in a Mouse Model of Plasma Lipid Lowering. Stem Cells. 30(12):2720-31, 2012.  PMCID: PMC3508339

Xing, J., Wang, Q., Coughlan, K., Viollet, B., Moriasi, CM., and Zou, M.H. Inhibition of AMP-Activated Protein Kinase Accentuates Lipopolysaccharides-Induced Lung Endothelial Barrier Dysfunction and Lung Injury in Vivo. Am. J. Pathol. 182(3):1021-30, 2013.  PMCID: PMC3589075

Liang, B, Wang, S., Wang, Q., Zhang, W., Viollet, B., Zhu, Y., Zou, M.H. Aberrant Endoplasmic Reticulum Stress in Vascular Smooth Muscle Increases Vascular Contractility and Blood Pressure in Mice Deficient of AMP-activated Protein Kinase alpha 2 in vivo. ATVB. 33(3):595-604, 2013.  PMCID: PMC Journal - In Process

Yang, S, Chen, C, Wang, H, Rao, X, Wang, F, Duan, Q, Chen, F, Long, G, Gong, W, Zou, M. H., Wang, DW. Protective effects of acyl-coA thioesterase 1 on diabetic heart via PPARα/PGC1α signaling. PLoS One. 7(11):e50376, 2012.  PMCID: PMC3511550

Xu, J., Wang, S., Viollet, B., and Zou, M.H, Regulation of proteasome by AMPK: The role of O-GlcNAc transferase (OGT). Plos One. 7(5):e36717, 2012.  PMCID: PMC3345026

Wu, Y., Wang, S., Xu, J., Song, P., Viollet, B., and Zou M.H. Activation of the AMP-activated Protein Kinase by Eicosapentaenoic Acid (EPA, 20:5 n-3) Improves Endothelial Function in vivo. Plos One. 7(4):e35508, 2012.  PMCID: PMC3330125

Song, P. and Zou, M.H. (Invited Review) Regulation of NAD(P)H oxidases by AMPK in cardiovascular systems. Free Radical Biol. Med. 52(9):1607-19, 2012.  PMCID: PMC3341493

Wang, S., Zhang C., Liang, B., Zhang, M., Lee, J., Zhu, H., Viollet, B., Xia, L., Zhang Y., and Zou, M.H. Activation of AMP-activated Protein Kinase alpha2 by Nicotine Instigates the Formation of the Abdominal Aortic Aneurysms in Mice in vivo.  Nature Medicine 18(6):902-10, 2012 (Accompanied with editorial commentary).  PMCID: PMC3559018

Wang, S., Song, P., Zou, M.H. Inhibition of AMPKα1 by doxorubicin accentuates genotoxic stress and cell death in mouse embryonic fibroblasts: role of p53 and SIRT1. J. Biol. Chem. 287(11):8001-12, 2012.  PMCID: PMC3318690

Wang, S., Song, P., Zou, M.H. AMP-activated Protein Kinase, Stress Responses, and Cardiovascular Diseases. Clinical Science 122, 555–573, 2012.  PMCID: PMC3367961

Xu, J., Wang, S., Zhang, M., Wang, Q., Asfa, S., Zou, M.H. Tyrosine nitration of PA700 links proteasome activation to endothelial dysfunction in mouse models with cardiovascular risk factors. PloS One 7(1):e29649, 2012.  PMCID: PMC3260160

Wu, Y., Dong, Y., Song, P., Zou, M-H. Activation of the AMP-activated Protein Kinase (AMPK) by Nitrated Lipids in Endothelial Cells. PloS One 7(2):e31056, 2012.  PMCID: PMC3281919

Song, P., Wang, S., He, C., Wang, S., Liang, B., Zhang, W., Zou, M.H. AMPKα2 Deletion Exacerbates Neointimal Formation by Upregulating Skp2 in Vascular Smooth Muscle Cells in vivo. Circ Res. 109(11):1230-9, 2011.  PMCID: PMC3260825

Zou, M.H, Li, H., He, C., Lyons, T., Xie, Z. Tyrosine Nitration of Prostacyclin Synthase Is Associated with Enhanced Retinal Cell Apoptosis in Diabetes. Am. J. Path. 179:2835–2844, 2011.  PMCID: PMC3260825

Shirwany, N. and Zou,M.H. Vascular inflammation as a missing link for enhanced cardiovascular diseases in diabetes. Frontier in Bioscience (Landmark Edition, Invited Review). 17:1140-64, 2012.

Wang, Q., Liang, B., Zhang, M., Viollet, B., Zhu, Y., Zou, M.H. Berberine Attenuates Oxidative Stress and Atherosclerosis in Mice in vivo: Roles of the AMP-activated Protein Kinase. PloS One 6(9):e25436, 2011.

Zhu Z, Fu C, Li X, Song Y, Li C, Zou, M.H, Guan Y, Zhu Y. Prostaglandin E2 Promotes Endothelial Differentiation from Bone Marrow-Derived Cells through AMPK Activation. PLoS One 6(8):e23554, 2011.

Xie Z, He C, Zou M.H. AMP-activated protein kinase modulates cardiac autophagy in diabetic cardiomyopathy. Autophagy. 7(10):1254-5, 2011.

Xie Z, Lau K,  Eby B,  Lozano P, He C, Pennington B, Dong Y,  Rathi S, Tian R, Kem D,  Zou MH. Improvement of Cardiac Functions by Chronic Metformin Treatment Is Associated With Enhanced Cardiac Autophagy in Diabetic OVE26 Mice. Diabetes. 60(6):1770-8, 2011.

Xu, M., Song, P., Shirwany, N., Xing, Viollet, B., J., Wang, X., Zhu, Y., Zou, M.H.Impaired Expression of Uncoupling Protein 2 (UCP-2) Causes Defective Post-ischemic Angiogenesis in Mice Deficient of AMP-activated Protein Kinase α2 Subunits. ATVB. 31:1757-1765, 2011.

Wand S, Laing B, Viollet B, Zou MH. Inhibition of AMP_activated Protein Kinase-alpha)2 Accentuates Agonist Induced Vascular Smooth Muscle Contraction and High Blood Pressure in Mice. Hypertension. 2011 May; 57(5): 1010-7 ePub 2011 Apr 4

Wang Q, Liang B, Shirwany NA, Zou MH . 2-Deoxy-D-Glucose Treatment of Endothelial Cells Induces Autophagy by Reactive Oxygen Species-Mediated Activation of AMP-activated Protein Kinase. PLoS One. 2011 Feb 28;6(2):e17234

Zou MH. Is NAD(P)H Oxidase a Missing Link for Air Pollution-enhanced Obesity?  Arterioscler Throm Vasc Biol. 2010 Dec;31(12):2323-4

Han Y, Wang Q, Song P, Zhu Y, Zou MH. Redox Regulation of the AMP-activated Protein Kinase. PLoS One. 2010 Nov 5;5(11):e15420

Zhang M, Song P, Xu J, Zou MH. Activation of NAD(P)H Oxidases by Thromboxane A2 Receptor Uncouples Endothelial Nitric Oxide Synthase.  Arterioscler Thromb Vasc Biol. 2011 Jan; 31(1):125-132. Epub 2010 Oct 14.

Shirwany NA, Zou MH. Arterial stiffness: a brief review. Acta Pharmacol Sin. 2010 Oct;31(10):1267-76. Epub 2010 Aug 30.

Shirwany NA, Zou MH. AMPK in cardiovascular health and disease. Acta Pharmacol Sin. 2010 Sep;31(9):1075-84. Epub 2010 Aug 16.

Wang S, Dale GL, Song P, Viollet B, Zou MH. AMPKalpha1 deletion shortens erythrocyte life span in mice: role of oxidative stress. J Biol Chem. 2010 Jun 25;285(26):19976-85. Epub 2010 Apr 14.

Li YJ, Wang PH, Chen C, Zou MH, Wang DW. Improvement of mechanical heart function by trimetazidine in db/db mice. Acta Pharmacol Sin. 2010 May;31(5):560-9. Epub 2010 Apr 12.

Dong Y, Zhang M, Wang S, Liang B, Zhao Z, Liu C, Wu M, Choi HC, Lyons TJ, Zou MH. Activation of AMP-activated protein kinase inhibits oxidized LDL-triggered endoplasmic reticulum stress in vivo. Diabetes. 2010 Jun;59(6):1386-96. Epub 2010 Mar 18.

Liu C, Liang B, Wang Q, Wu J, Zou MH. Activation of AMP-activated protein kinase alpha1 alleviates endothelial cell apoptosis by increasing the expression of anti-apoptotic proteins Bcl-2 and survivin. J Biol Chem. 2010 May 14;285(20):15346-55. Epub 2010 Mar 16.

Wang S, Zhang M, Liang B, Xu J, Xie Z, Liu C, Viollet B, Yan D, Zou MH. AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: role of 26S proteasomes. Circ Res. 2010 Apr 2;106(6):1117-28. Epub 2010 Feb 18.

Dong Y, Zhang M, Liang B, Xie Z, Zhao Z, Asfa S, Choi HC, Zou MH. Reduction of AMP-activated protein kinase alpha2 increases endoplasmic reticulum stress and atherosclerosis in vivo.  Circulation. 2010 Feb 16;121(6):792-803. Epub 2010 Feb 1.

Xu J, Zou MH. Molecular insights and therapeutic targets for diabetic endothelial dysfunction. Circulation. 2009 Sep 29;120(13):1266-86. Review. No abstract available.

Xu J, Wang S, Wu Y, Song P, Zou MH. Tyrosine nitration of PA700 activates the 26S proteasome to induce endothelial dysfunction in mice with angiotensin II-induced hypertension.
Hypertension. 2009 Sep;54(3):625-32. Epub 2009 Jul 13.

Wang S, Xu J, Song P, Viollet B, Zou MH. In vivo activation of AMP-activated protein kinase attenuates diabetes-enhanced degradation of GTP cyclohydrolase I. Diabetes. 2009 Aug;58(8):1893-901. Epub 2009 Jun 15.

Xie Z, Dong Y, Zhang J, Scholz R, Neumann D, Zou MH. Identification of the serine 307 of LKB1 as a novel phosphorylation site essential for its nucleocytoplasmic transport and endothelial cell angiogenesis. Mol Cell Biol. 2009 Jul;29(13):3582-96. Epub 2009 May 4.

Song P, Zhang M, Wang S, Xu J, Choi HC, Zou MH. Thromboxane A2 receptor activates a Rho-associated kinase/LKB1/PTEN pathway to attenuate endothelium insulin signaling. J Biol Chem. 2009 Jun 19;284(25):17120-8. Epub 2009 Apr 29.

Xie Z, Zhang J, Wu J, Viollet B, Zou MH. Upregulation of mitochondrial uncoupling protein-2 by the AMP-activated protein kinase in endothelial cells attenuates oxidative stress in diabetes. Diabetes. 2008 Dec;57(12):3222-30. Epub 2008 Oct 3.

Zhang J, Xie Z, Dong Y, Wang S, Liu C, Zou MH. Identification of nitric oxide as an endogenous activator of the AMP-activated protein kinase in vascular endothelial cells. J Biol Chem. 2008 Oct 10;283(41):27452-61. Epub 2008 Aug 7.

Wang S, Xu J, Song P, Wu Y, Zhang J, Chul Choi H, Zou MH. Acute inhibition of guanosine triphosphate cyclohydrolase 1 uncouples endothelial nitric oxidate synthase and elevates blood pressure. Hypertension. 2008 Sep;52(3):484-90. Epub 2008 Jul 21.

Dong Y, Wu Y, Wu M, Wang S, Zhang J, Xie Z, Xu J, Song P, Wilson K, Zhao Z, Lyons T, Zou MH. Activation of protease calpain by oxidized and glycated LDL increases the degradation of endothelial nitric oxide synthase. J Cell Mol Med. 2009 Sep;13(9A):2899-910. Epub 2008 Jun 28.

Zhang SX, Wang JJ, Dashti A, Wilson K, Zou MH, Szweda L, Ma JX, Lyons TJ. Pigment epithelium-derived factor mitigates inflammation and oxidative stress in retinal pericytes exposed to oxidized low-density lipoprotein. J Mol Endocrinol. 2008 Sep;41(3):135-43. Epub 2008 Jun 27.

Choi HC, Song P, Xie Z, Wu Y, Xu J, Zhang M, Dong Y, Wang S, Lau K, Zou MH. Reactive nitrogen species is required for the activation of the AMP-activated protein kinase by statin in vivo. J Biol Chem. 2008 Jul 18;283(29):20186-97. Epub 2008 May 12.

Song P, Xie Z, Wu Y, Xu J, Dong Y, Zou MH. Protein kinase Czeta-dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cells.  J Biol Chem. 2008 May 2;283(18):12446-55. Epub 2008 Mar 5.

Xie Z, Dong Y, Scholz R, Neumann D, Zou MH. Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cells. Circulation. 2008 Feb 19;117(7):952-62. Epub 2008 Feb 4.

Zou MH, Wu Y. AMP-activated protein kinase activation as a strategy for protecting vascular endothelial function. Clin Exp Pharmacol Physiol. 2008 May;35(5-6):535-45. Epub 2007 Dec 26. Review.

Zhang M, Dong Y, Xu J, Xie Z, Wu Y, Song P, Guzman M, Wu J, Zou MH. Thromboxane receptor activates the AMP-activated protein kinase in vascular smooth muscle cells via hydrogen peroxide. Circ Res. 2008 Feb 15;102(3):328-37. Epub 2007 Dec 6.

Wenzel P, Daiber A, Oelze M, Brandt M, Closs E, Xu J, Thum T, Bauersachs J, Ertl G, Zou MH, Förstermann U, Münzel T. Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus. Atherosclerosis. 2008 May;198(1):65-76. Epub 2007 Dec 3.

Song P, Wu Y, Xu J, Xie Z, Dong Y, Zhang M, Zou MH. Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent manner. Circulation. 2007 Oct 2;116(14):1585-95. Epub 2007 Sep 17.

Xu J, Wu Y, Song P, Zhang M, Wang S, Zou MH. Proteasome-dependent degradation of guanosine 5'-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitus. Circulation. 2007 Aug 21;116(8):944-53. Epub 2007 Aug 6.

An Z, Wang H, Song P, Zhang M, Geng X, Zou MH. Nicotine-induced activation of AMP-activated protein kinase inhibits fatty acid synthase in 3T3L1 adipocytes: a role for oxidant stress. J Biol Chem. 2007 Sep 14;282(37):26793-801. Epub 2007 Jul 16.

Wu Y, Song P, Xu J, Zhang M, Zou MH. Activation of protein phosphatase 2A by palmitate inhibits AMP-activated protein kinase. J Biol Chem. 2007 Mar 30;282(13):9777-88. Epub 2007 Jan 25.

Zou MH. Peroxynitrite and protein tyrosine nitration of prostacyclin synthase. Prostaglandins Other Lipid Mediat. 2007 Jan;82(1-4):119-27. Epub 2006 Jun 21. Review.

Nie H, Wu JL, Zhang M, Xu J, Zou MH. Endothelial nitric oxide synthase-dependent tyrosine nitration of prostacyclin synthase in diabetes in vivo. Diabetes. 2006 Nov;55(11):3133-41.

Xu J, Xie Z, Reece R, Pimental D, Zou MH. Uncoupling of endothelial nitric oxidase synthase by hypochlorous acid: role of NAD(P)H oxidase-derived superoxide and peroxynitrite. Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2688-95. Epub 2006 Oct 5.

Du X, Edelstein D, Obici S, Higham N, Zou MH, Brownlee M. Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation. J Clin Invest. 2006 Apr;116(4):1071-80. Epub 2006 Mar 9.

Davis BJ, Xie Z, Viollet B, Zou MH.  Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase. Diabetes. 2006 Feb;55(2):496-505.

Xie Z, Dong Y, Zhang M, Cui MZ, Cohen RA, Riek U, Neumann D, Schlattner U, Zou MH. Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells. J Biol Chem. 2006 Mar 10;281(10):6366-75. Epub 2006 Jan 9.