Research

The current research focus of our section is to dissect molecular insights of cardiovascular remodeling in obesity and obesity related diseases including diabetes, hypertension, heart diseases, and stroke, with special emphasis on the regulation of these processes. Utilizing a multidisciplinary approach encompassing all aspects of modern biology, including structural biology, cell biology, protein chemistry, structure-function analysis of enzymes and receptors, regulation of the relevant genes, and in vivo studies using transgenic and gene deletion approaches, scientists in the section of Molecular Medicine employ physical, chemical, biological and medical techniques to describe molecular structures and mechanisms, identify fundamental molecular and genetic errors of disease, and to develop molecular interventions to correct them. Our multidisciplinary approach allows identification of new factors and the mechanisms that regulate over nutrition, obesity and inflammation and enables translation of these findings into an appreciation of their physiological role and clinical relevance. The section has identified novel mechanisms involved in vascular damage which may evolve into therapeutically successful prevention and treatment strategies.  The research is published in the most prestigious biology and medical journals and has garnered more than $23 million from the National Institutes of Health, American Heart Association, American Diabetes Association, and others over the last 5 years.

(For further details of our research, please explore the publications link.)