Lawrence E De Bault, PhD

Lawrence E. Debault, PhD

The University of Oklahoma
Health Sciences Center
O'Donoghue Rehabilitation Institute 
1122 N.E. 13th
Room 333B 
Oklahoma City, Oklahoma  73104

PHONE:  (405)  271-7300

E-MAIL:  Lawrence De Bault

TITLES

Professor of Pathology
Research/Flow Cytometry

Affiliate Member of the
Oklahoma Medical Research Foundation

EDUCATION

Victoria College
Victoria, Texas
A.A.-General Science (1961)

University of Texas
Austin, Texas
B.S. S. Ed.-Biological Sciences Major: Zoology Minor: Botany, Chemistry, Education (1964)

University of Stockholm
Stockholm,Sweden
Ph.D.-Biology/Cell Physiology (1969)

Research Interests/Sub-Specialty

Between my laboratory and those with which I collaborate, there are three major areas of on-going research. One area deals with the induction and maintenance of differentiated properties and functions of the blood-brain barrier endothelium and the role that glial cells play. Included in these studies are those designed to investigate the synthesis and expression of ectoenzymes that participate in the control of the cell's local environment, i.e., angiotensin converting enzyme, aminopeptidase A, aminopeptidase N, dipeptidyl-peptidase IV, and gamma-glutamyl transpeptidase.

A second and new area of research involves several investigators in different laboratories, and deals with the comparative studies between human and animal models. Work on human and animal cells is expected to tell us more about the effectiveness of laser biostimulation, cell-mediator and hormone treatment, and the grafting of cells into injured synovial membrane, epiphyseal bone and cartilage. This work is being conducted in the newly-established "Comparative Orthopaedic Research Laboratory", which is co-directed jointly by Dr. DeBault of the Department of Animal Sciences, University of Hawaii at Hilo, Hawaii.

A third area of research involves flow cytometry, cell sorting, image analysis, and several other forms of quantitative microscopy (at both the light and electron microscopic levels), and their application to the diagnosis and prognosis of patients with different kinds of tumors in both human cases and animal tumor models.

PUBLICATIONS

  1. De Bault LE, Wang BL, and Grammas P. Expression of vascular enzymes during the process of cellular aggregation and tube formation in endothelial cell cultures from rat cerebral resistance vessels: An enzyme cytochemical study. Cell Vision. 1996; 3:90-95.

  2. Pullin JG, Collier MA, Das P, Smith RL, De Bault LE, Johnson LL, and Walls RC. Effects of holmium: YAG laser energy on cartilage metabolism, healing and biochemical properties of lesional and peri-lesional tissue in a weight bearing model.Arthroscopy 1996; 12:15-25.

  3. Collier MA, Clark D, De Bault LE, Thompson H., White GW, Walls R, and Hamm J. The distribution of radio-labeled PSGAG in canine synovial fluid and articular cartilage after intramuscular injection of 3H-PSGAG. Orthopedics. 1998; 23: 6-9.

  4. Taylor FB, Tesh VL, De Bault LE, Li A, Chang ACK, Kosanke SD, Pyscher T, and Siegler. Characterization of the baboon responses to shiga-like toxin: Descriptive study of a new primate model of toxic responses to Stx-1. Am. J. Path.  1999; 154: 1285-1299.

  5. Gaffey TA Jr, Scheithauer BW, Leech RW, Blick K, Kovacs K, Horvath E, Weaver AL, Lloyd RV, Ebersold M, Laws ER Jr, DeBault LE.  Pituitary adenoma: a DNA flow cytometric study of 192 clinicopathologically characterized tumors. Clin Neuropathol. 2005 Mar-Apr;24(2):56-63.

  6. De Bault LE.  Editorial.  J Mol Histol. 2004 Aug;35(6):541-3.

  7. DeBault LE, Tubbs RR.  Tissue microarrays: robust molecular morphology tools.  J Mol Histol. 2007 May;38(2):111-2.