B-cell Acute Lymphatic Leukemia (ALL) panel

It is also called acute lymphoblastic leukemia or acute lymphocytic leukemia and is abbreviated as ALL. It is a rapidly progressing form of leukemia that is characterized by the presence of large numbers of unusually immature white blood cells destined to become lymphocytes.  

Some factors associated with an increased risk of ALL have been identified. The main environmental factor is radiation, namely prenatal exposure to x-rays or postnatal exposure to high doses of radiation. Children with Down syndrome also have an increased risk for both ALL and acute myeloid leukemia (AML). Increased occurrence of ALL is also associated with certain genetic conditions, including neurofibromatosis, Shwachman syndrome, Bloom syndrome, and ataxia telangiectasia.

Common chromosome changes observed:

TEL/AML1  t(12;21)(p13;q11.2)
BCR/ABLt(9;22)(q34;q11.2)
PBX1/TCF3 t(1;19)(q23;p13.2)
p6/9cen –9/9p deletion or +9
4cen/10cen/17cen
MLL 11q23 rearrangements
AF4/MLL t(4;11)(q21;q23)
MLL,ENL t(11;19)(q23;p13.3)

Methodology: Fluorescent in Situ Hybridization (FISH) Analysis

Purpose: Confirmation of Clinical Diagnosis/Monitor During Treatment

ICD-9 Diagnosis Code: 204.10

Test Requisition: Cancer Cytogenetics Requisition

CPT Codes: 88271, 88275, 88291 Cost: $341.00 one probe

Turn-around-time: 2-5 days