Chronic Myelogenous Leukemia (CML) 

Chronic myelogenous leukemia is commonly called CML. It is also known as chronic myelocytic leukemia and chronic granulocytic leukemia. CML is a chronic malignant disease in which too many white blood cells belonging to the myeloid line of cells are made in the bone marrow. Early symptoms of this form of leukemia include fatigue, night sweats, fever, lack of appetite, and the spleen may be swollen and markedly enlarged.

CML is caused by a chromosome abnormality called the Philadelphia chromosome. Discovered in 1960, the Philadelphia chromosome is an abnormally short chromosome 22 that is one of the two chromosomes involved in a translocation with chromosome 9. This translocation takes place in a single bone marrow cell and, through the production of many cells from this one mutant cell, it gives rise to the leukemia.

Common chromosome changes: BCR/ABL t(9;22)(q34;q11.2)

Methodology: Fluorescent in Situ Hybridization (FISH) Analysis

Purpose: Confirmation of Clinical Diagnosis/Monitor During Treatment

ICD-9 Diagnosis: 205.10
 
Test Requisition:Cancer Cytogenetics Requisition

CPT Codes: 88271, 88275, 88291 Cost: $341.00 one probe

Turn-around-time: 2-5 days