Multiple Myeloma panel

Multiple Myeloma, also known as plasma cell myeloma, is usually seen in older adults. Patients present with osteolytic bone lesions, bone marrow infiltration and monoclonal gammopathy. A normal individual can synthesize the five classes of immunoglobulin but a patient with multiple myeloma produces a single immunoglobulin to excess and the synthesis of normal immunoglobulins is suppressed. Thus, the patient is said to have monoclonal gammopathy.

Common chromosome changes associated with Multiple Myeloma:

IGH  14q32 rearrangements
CCND1 t(11;14)(q13;q32)
p53/17cen –17/17p deletion
RB1/LAMP1 –13/13q deletion
9cen/15cen +9 and  +15
3cen/7cen +3 and +7
c-MAF t(14;16)(q32;q23)
FGFR3 t(4;14)(p16.3;q32)

Methodology: Fluorescent in Situ Hybridization (FISH) Analysis

Purpose: Confirmation of Clinical Diagnosis/Monitor During Treatment

ICD-9 Diagnosis: 203.00

Test Requisition: Cancer Cytogenetics Requisition

CPT Codes: 88271, 88275, 88291 Cost: $341.00 one probe

Turn-around-time: 2-5 days