Hereditary Breast and Ovarian Cancer Sequencing (known familial mutations only)

Hereditary Breast and Ovarian Cancer (HBOC) is a rare disorder, estimates are that they account for no more than 5 percent to 10 percent of all breast and ovarian cancer cases. HBOC is most frequently diagnosed when there are multiple cases of breast cancer and/or ovarian cancer on the same side of the family. In families with four or more cases of breast cancer diagnosed before age 60, the chance of HBOC is approximately 80%.

Mutations in BRCA1and BRCA2 are associated with HBOC. Both BRCA1 and BRCA2 are tumor suppressor genes that control cell growth and cell death. Everyone has two BRCA1 (one on each chromosome #17) and two BRCA2 genes (one on each chromosome #13). When a person has one altered or mutated copy of either the BRCA1 or BRCA2 gene, their risk for various breast, ovarian, prostate, larygeal, stomach cancer and melanoma cancers increases.

Our laboratory provides testing for known mutations for family members of affected individuals.

Methodology: Sequencing for known mutation

Purpose:Testing for known mutation in family member(s) of affected individual

Test Requisition: Sequencing Requisition

CPT Code: 81215 BRCA1 known variant

CPT Code: 81217 BRCA2 known variant

Cost: $333.00 each test

Turn-around-time: 3-4 weeks