Melanoma Sequencing

Cyclin-dependent kinase inhibitor 2A, (CDKN2A, p16) also known as multiple tumor suppressor 1 (MTS-1), is a tumor suppressor protein, that in humans is encoded by the CDKN2A gene. P16 plays an important role in regulating the cell cycle. Mutations in p16 increase the risk of developing a variety of cancers. Studies have shown mutations in CDKN2A contribute to 10-39% of hereditary form of malignant melanoma. Other studies have also shown an increased risk for pancreatic cancer in families with a CDKN2A mutation.

The mutation is inherited in an autosomal dominant manner. Chromosome locus 9p21.3.

Methodology: Sequencing of entire coding region

Purpose: Confirmation of Clinical Diagnosis

Test Requisition: Sequencing Requisition

CPT Code: 81404 Cost: $548.00

Turn-around-time: 3-4 weeks