Dharambir K. Sanghera, PhD

DK-3

Professor of Pediatrics Genetics (Tenured)
Adjunct Professor of Pharmaceutical Sciences
Member, Harold Hamm Diabetes Center
Member, Oklahoma Center for Neuroscience
phone: 405.271.8001 x.16026
email: Dharambir-Sanghera@ouhsc.edu

RESEARCH INTERESTS 

Diabetes, Cardiovascular diseases, Obesity, Genetics, and Genomics


PERSONAL STATEMENT

Dr. Sanghera's research is focused on efforts to understand the interplay between environmental and genetic factors involved in type 2 diabetes, obesity, and cardiovascular disease pathogenesis. Rising epidemic of cardiometabolic diseases is a growing public health problem among the immigrant populations in the US, particularly in the ethnicities that have migrated from rural areas to westernized urban environments. The reasons underlying these conditions are not understood. The aim of Dr. Sanghera’s research is to identify genetic susceptibility underlying these conditions in Asian Indians from India and minority populations of US including South Asians, Hispanics who are first generation immigrants and residents of states of Oklahoma, Texas, and California. United States of America. These populations have high predisposition for developing central obesity associated with metabolic and cardiovascular diseases when exposed to western diet and obesogenic environment.

Dr. Sanghera’s laboratory is currently employing genome‐wide linkage, genome‐wide association, and linkage disequilibrium approaches on family‐ and population‐based datasets, and also examining the functional role of novel variants with insulin resistance, beta‐cell dysfunction using tissue‐specific gene‐expression studies. The long‐term goals of Dr. Sanghera’s research are; 1) to identify the underlying molecular mechanisms associated with these disorders, 2) to improve the classification of the disease process by identifying genome‐wide patterns associated with ethnic variation, and 3) to discover new gene‐based targets based on ethnic origin and environmental and cultural differences which can inform the design of early prevention and treatment therapy among immigrant populations.

Dr. Sanghera is an International Fellow of the American Heart Association, serve on the Council on Atherosclerosis Thrombosis and Vascular Biology and Council of Basic Cardiovascular Sciences of American Heart Association. She also is South Central Affiliate of the American Heart Association since 2009. She has served on several Study Section panels of National Institute of Health, and many international grant review panels. She served on Expert Panel on Diabetes Round Table, provided service on Editorial Boards of eight journals and is a Lead Academic Editor of Biomed Research International. She is directing and teaching graduate level courses, has mentored and supervised undergraduate, graduate and post-doctoral staff. 

Our genetic epidemiology laboratory at OUHSC has been supported by NIH grants from FIC, NHLBI and NIDDK and funds from the Department of Paediatrics, University of Oklahoma (OUHSC) Center for Neuroscience, Harold Hamm Diabetes Center, and Presbyterian Health Foundation, and  Sarkey’s Foundation,  Sanghera’s group has published extensively in the area of cardiovascular/ diabetes genetics, and contributed in the identification of several novel genes for type 2 diabetes, coronary heart disease, vitamin D deficiency, shorter telomere length, blood lipids and  cardiovascular risk.  This lab provides an excellent opportunity for a highly-motivated student with a background molecular/cell biology, computational biology to receive training in gene-discovery studies during this uniquely-exciting time of applying human genetics in developing effective therapies.

Sanghera Genetic Epidemiology Lab

Dr. Sanghera's research specializes in the study of molecular and genetic epidemiological aspects of common complex diseases including non-insulin dependent diabetes mellitus (T2D), coronary heart disease, hypertension, and metabolic syndrome. Common traits with complex inheritances have both genetic and environmental causes. 

EDUCATION 

Fellowship: 1993-1995, Genetic Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA
Fellowship: 1992-1993, Molecular Mutagenesis, Graduate School of Public Health, University of Pittsburgh, PA
Ph. D.:  1992, Human Genetics, Guru Nanak Dev University, Amritsar, India

TEACHING

GENC6002/PHSC6002/ OCNS6002 (2010- present) Pharmacogenomics: The Foundation of Personalized Medicine

PHYO 6401 (2012-present) Cardiovascular Genomics and Diseases   

GENC 5011 (2012-present) Topics in genetic counseling 2012-present

INDT 8108 (2014-present) Molecular and Cellular Systems 

PUBLICA​TIONS

http://www.ncbi.nlm.nih.gov/pubmed/?term=dharambir+sanghera