Bhatti_Faizah_2

Faizah Bhatti, MD, MS
Assistant Professor
Neonatologist

Expertise:
Retinopathy; Retinal Development; Retinopathy of Prematurity (ROP); Vascular Biology of the Central Nervous System; Neonatal-Perinatal Medicine
 
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Education:
The Aga Khan University Medical College, Karachi, Pakistan   MBBS - 1998
Residency: Penn State Milton S. Hershey Medical Center, Hershey, PA – 2007
Post-Doctoral Fellowship, Cell Biology : Georgetown University Medical Center, Washington D.C.- 2004
​Neonatology Fellowship: Milton S. Hershey Medical Center Children’s Hospital, Hershey, PA- 2010
Master of Science, Health Evaluation Sciences: Penn State College of Medicine, Hershey, PA- 2011 ​


With training in medical sciences as well as cell and molecular biology, Dr. Faizah Bhatti has pursued a track of translational/basic science research. Dr. Bhatti’s medical degree was completed at the Aga Khan University in Pakistan in 1998. She then completed a cell biology post-doctoral fellowship at Georgetown University, followed by residency training in pediatrics and an academic fellowship in neonatal medicine, both at the Penn State University Medical Center. During fellowship, Dr. Bhatti became interested in the biology of surfactant proteins and in their role as inflammatory mediators. She continued her work when she was recruited to the Children’s Hospital at OUHSC as a clinician scientist in 2011. Dr. Bhatti holds academic appointments in the Department of Pediatrics, Ophthalmology and the Oklahoma Center for Neurosciences. Collaborating with retinal, brain and immune experts, she is an independently funded clinician scientist studying inflammatory vascular biology. Her background and training give her an understanding of both the clinical relevance as well as the methodology needed to scientifically address clinical complications of extreme prematurity.  

Dr. Bhatti examines the biological and molecular roles of inflammatory mediators on vascular development, structure and function in both retinal as well as cerebral vascular beds. Simultaneously, she utilizes clinical data on preterm infants to study associations between inflammation, sepsis, growth and retinopathy in premature infants. She is a principal investigator/sub-PI for several clinical trials involving therapeutics and clinical aspects of ROP in the neonatal subjects at OUHSC. She has trained several residents, fellows and students in her lab program, several of whom who gone on to pursue academic fellowships and have contributed to the publications from their research program. Dr. Bhatti is committed to caring for premature babies and finding cures based on sound evidence and science. 

Current Lab Members:

Johannes Kung, PhD- Research associate & Lab manager
Frederico Vieira, MD- Neonatology Fellow
Michael Melek, MD- Neonatology Fellow
Erica Marxen, BS- Graduate Student

 

Lab

Dr. Vieira


Bhatti


Bhatti presents

Basic Science Projects:

  1. Novel Inflammatory Mediators (Collectin Surfactant Protein A) in Oxygen Induced Retinopathy, Retinal Inflammation and Neoproliferation
    1. The effect of SP-A on human and murine retinal endothelial morphology and function
  2. Effect of Systemic Inflammation and Hyperoxia On Neonatal Retinal Vascular Development
  3. Collectin Surfactant Protein D in Oxygen Induced Retinopathy, Retinal Inflammation and Neoproliferation
  4. Role of the collectin proteins SP-A and SP-D in cerebrovascular complications of prematurity

Translational Science Projects:

  1. Allelic Variants of Surfactant Protein A In Neonates With Proliferative Retinopathy: Population Based Study of Allelic Variants of Surfactant Protein A in Premature Infant

Clinical Projects:

  1. Determination of the rhIGF-1/rhIGFBP-3 Dose, administered as a Continuous Infusion, required to Establish and Maintain Longitudinal Serum IGF-1 Levels Within Physiological Levels in Premature Infants, to Prevent Retinopathy of Prematurity.
    1. Phase IID- determination of dose, safety and adverse events
    2. PEDAL- Long term effects of rhIGF-1/rhIGFBP-3
    3. Footprints- PhaseII/III study
  1. Phase I Trial of Bevacizumab Treatment for Severe Retinopathy of Prematurity
  2. Clinical Patterns of Sepsis/Infections in Premature Neonates with Retinopathy of Prematurity
  3. Incidence and Severity of Retinopathy of Prematurity in Infants over 32 weeks Gestational Age
  4. Delayed Onset, Progression, and Regression of Retinopathy of Prematurity in Extremely Premature Infants
  5. Growth and Retinopathy of Prematurity Registry

Lab

presentation

Selected Publications:
Vieira F, Kung JW, Bhatti F. Structure, genetics and function of the pulmonary associated surfactant proteins A and D: The extra-pulmonary role of these C type lectins. Ann Anat. 2017 Mar 27. [Epub ahead of print] 

Bhatti F, Pulmonary Surfactant Protein A Is Expressed in the Mouse Retina by Muller Cells Impacts Neovascularization in Oxygen Induced Retinopathy, Invest Ophthalmol Vis Sci November 18, 2014 IOVS-13-13652.

Gu X, Reagan A, Yen A, Bhatti F, Cohen AW, Elliott MH. Spatial and Temporal Localization of Caveolin-1 Protein in the Developing Retina. Adv Exp Med Biol. 2014;801:15-21.

Noutsios GT, Silveyra P, Bhatti F, Floros J. Exon B of human surfactant protein A2 mRNA, alone or within its surrounding sequences interacts with 14-3-3; role of cis elements and secondary structure. Am J Physiol Lung Cell Mol Physiol. 2013 Mar 22.

Bhatti F
. Transient Tachypnea of the Newborn. Pediatrics A Competency-Based Companion. Ed; McMahon,M, Stryjewski, G, Elsevier, 2011.