The NICU at Children’s Hospital of Oklahoma is the state’s premier academic center for newborn intensive care.  All faculty members pursue clinical or bench research activities, with a wide range of scholarly interests mirrored by a diverse and multi-faceted research agenda. In addition to single-center studies, we reach out beyond our NICU to establish cooperative joint projects with national and international researchers.


Szyld_Eduardo

Dr. ​Edgardo Szyld, MD, MSc
Director of Research
Professor 
Neonatologist

Dr. Edgardo Szyld serves as the Director of Research for the section of Neonatal-Perinatal medicine. His extensive experience in designing, organizing, conducting and analyzing multicenter clinical trails, combined with more than 30 years of successfully mentoring medical trainees, fellows and faculty in research make him an invaluable resource for leading all section faculty, trainees and staff in all aspects of basic and clinical research, from project design through peer-reviewed publications. Dr. Szyld has developed and supervises both a robust research training program, as well as an extensive team of research specialists to assist faculty researchers. Together, these initiatives allow researchers to gain the knowledge needed to successfully design, conduct and publish basic and clinical research and provide them with the support staff needed to make their research both feasible and cost-effective.

Resuscitation and stabilization:

Enríquez D, Lamborizio MJ, Firenze L, Jaureguizar MP, Díaz Pumará E, Szyld E, Training of resident physicians in the recognition and treatment of an anaphylaxis case in pediatrics with simulation models]. Arch Argent Pediatr. 2017 Aug 1;115(4):399-403. Spanish.

Enriquez, D., Meritano, J., Shah, B. A., Song, C. H., Szyld, E. G. (in press). Fatigue During Chest Compression Using a Neonatal Patient Simulator. Am J of Perinatol DOI https://doi.org/10.1055/s-0037-1620231.ISSN 0735-1631.

Diego Enriquez, Raúl Gómez Traverso, Silvina Brizuela, Edgardo Szyld, Mistakes in Drug Prescription During simulated Pediatric Resuscitations and Other Urgency Procedures, Arch Argent Pediatr 2017;115(3):294-299 / 294

Berazategui J, Aguilar A, Escobedo M, Dannaway D, Guinsburg R, de Almeida B, Saker S, Fernandez A, Albornoz G, Valera M, Amado D, Puig G, Althabe F, Szyld E, Risk Factors for Advance Resuscitation in Term and Near-Term Infants: A Case-control Study, Arch Dis Child Fetal Neonatal Ed 2016;0:F1-F7. Doi:10.1136/archdischild-2015-309525.

Enriquez D, Mastandueno R, Szyld E, Relatives’ Presence During Cardiopulmonary Resuscitation, Global Hear Ref:  Ms. No. GHEART-D-15-00065R1

Hunt L, Hallford G, Robledo C, Szyld E, Song C, Impact Of Specialized Nursery Care For Late Preterm Infants On NICU Admission Rate And Length Of Stay, Am J Perinatol 2015 Nov;32(13): 1198-204 PMID: 26070121

Szyld E, Aguilar A, Musante GA, Vain N, Prudent L, Fabres J, Carlo WA; Delivery Room Ventilation Devices Trial Group. Comparison of Devices for Newborn Ventilation on the Delivery Room, J Pediatr. 2014 Aug;165(2):234-239.e3. doi: 10.1016/j.jpeds.2014.02.035. Epub 2014 Mar 29.

Tingay D, Polglase G, Bhatia R, Berry C, Kopotic R, Kopotic C, Song Y, Szyld E, Jobe A, Pillow J, Pressure-limited Sustained Inflation vervis Gradual Tidal Inflations for Resuscitation in Preterm Lambs, J Appl Physiol 2015 Jan 29:jap.00985.2014

Wlodaver A, Blunt M, Satnes K, Escobedo M, Hallford G, Szyld E, A retrospective comparison of VLBW outcomes before and after implementing new delivery room guidelines at a regional tertiary care center, J Perinatol 2015 Dec 3. Doi: 10.1038/jp.2015.187 [Epub ahead of print]

Retinopathy of prematurity (RoP)

Gurwin J, Tomlinson L, Quinn G, Ying G, Baumritter A, Binenbaum G, for the Postnatal Growth and Retinopathy of Prematurity (G-ROP) Study Group (R. Michael Siatkowski, Faizah Bhatti, Vanessa Bergman, Karen Corff, Kari Harkey, Amy Manfredo, Shrenik Talsania, Terri Whisenhunt) Telemedicine Approaches to Evaluating Acute-Phase Retinopathy of Prematurity (e-ROP) Cooperative Group (R. Michael Siatkowski, Lucas Trigler, Marilyn Escobedo, Karen Corff, Michelle Huynh-Blunt, Kelli Satnes), A Tiered Approach to Retinopathy of Prematurity Screening (TARP) Using a Weight Gain Predictive Model and a Telemedicine System, JAMA Ophthalmol. 2017;135(2):131-136.

Vieira F, Kung J, Bhatti F, Structure, Genetics and Function of the Pulmonary Associated Surfactant Proteins A and D: The Extra-pulmonary Role of These C Type Lectins, Annals of Anatomy 211 (2017) 184-201.

Binenbaum G, Tomlinson L, on behalf of the G-ROP Study Grou R. Michael Siatkowski, MD, Faizah Bhatti, MD, Vanessa Bergman, COT, CCRC, Karen Corff, APRN, NNP, Kari Harkey, RNC-NIC, Amy Manfredo, APRN-CNP, Shrenik Talsania, MBBS, MPH, CPH, and Terri Whisenhunt, MS, RNp: Postnatal Growth and Retinopathy of Prematurity Study: Rationale, Design, and Subject Characteristics. Ophthalm Epidem 24(1): 36-47, Feb 2017.

Kemper A, Prosser L, Wade K, Repka M, Ying G, Baumritter A, Quinn G for the e-ROP Study   Cooperative Group (Escobedo M) A Comparison of Strategies for Retinopathy of Prematurity   Detection, Pediatrics. 2016 Jan;137(1):1-10. Doi: 10.1542/peds. 2015-2256. Epub 2015 Dec 15

Wade K, Pistilli M, Baumritter A, Karp K, Gong A, Kemper Ying A Quinn G, on behalf of the e-Retinopathy of Prematurity Study Cooperative Group (Escobedo M), Safety of Retinopathy of Prematurity Examination and Imaging in Premature Infants, J Pediatr. 2015 Nov;167(5):994-1000 e2 doi: 10.1016/j peds 2015.07.050 Epub 2015 Aug 20.

Education:

Ernst, K. D., Dannaway, D, Knowledge of Equipment Preparation for Simulated Neonatal Intubation Sessions Decays within Six Months. J Okla State Med Assoc 2017 Jun-Jul;110(6):306-309

Enriquez D, Gomez Traverso G, Szyld E. Behavior of Pediatric Medical Residents During a Clinical Simulation of a Violent Mother in a Pediatric Emergency. Arch Argent Pediatr 2016;114(3):232-236

Song C, Neonatology Today Column: Playing it Safe in a Social World, Social and Mobile Media for the Neonatologist, Vol 9 (12), 9 Dec 2014

Song C, Neonatology Today Column: Applications for a Mobile Life in the Unit, Part 1 of 3 - Social and Mobile Media for the Neonatologist: Applications for a Mobile Life in the Unit, Vol 10 (3), 7-8 March 2015

Song C, Neonatology Today Column: Applications for a Mobile Life in the Office:  Part 2 of 3 – Social and Mobile Media for the Neonatologist, Vol 10 (5), 11-12  May 2015

Song, C, NT Column:  Social & Mobile Media for the Neonatologist:  Applications for a Mobile Life, In Life, Part 3 of 3, Neonatology Today, Vol 10 (9), 9 September 2015

Necrotizing Enterocolitis (NEC):

Shah BA, Migliori A, Kurihara I, Sharma S, Lim YP, Padbury J, Blood Level of Inter-Alpha Inhibitor Proteins Distinguishes Necrotizing Enterocolitis From Spontaneous Intestinal Perforation, J Pediatr. 2017 Jan;180:135-140.e1. doi: 10.1016/j.jpeds.2016.09.016. Epub 2016 Oct 10.

Eckert, J., Scott, B., Galluci, R., Lawrence, S., Chaaban, H. FLLL32 A curcumin analog, Ameliorates Intestinal Injury in Necrotizing Enterocolitis. Journal Of Inflammation Research 2017:10 75-81.

Shah BA, Mifliori A, Kurihara I, Sharma S, Lim YP, Padbury J, Blood Level of Inter-Alpha Inhibitor Proteins Distinguishes Necrotizing Enterocolitis From Spontaneous Intestinal Perforation, J Pediatr 2016 Oct 10. pii:S0022-3476(16)30926-X [Epub ahead of print].

Warner BB, Deych E, Zhou Y, Hall-Moore C, Weinstock GM, Sodergren E, Shaikh N, Hoffmann JA, Linneman LA, Hamvas A, Khanna G, Rouggly-Nickless LC, Ndao IM, Shands BA, Escobedo M, Sullivan JE, Radmacher PG, Shannon WD, Tarr PI, Gut Bacterial Dysbiosis and Necrotizing Enterocolitis in Very Low Birthweight Infants: A Prospective Case-Control Study, Lancet 2016 Mar;387:1928-36.

Gastroenterology and Nutrition

Willeitner A, Anderson M, Lewis J, Highly concentrated Preterm Formula as an Alternative to Powdered Human Milk Fortifier: A Randomized, Controlled Trial. J Pediatr Gastroenterol Nutr. 2017 Nov;65(5):574-578.

Ernst, K. D. (2017). Essential Fatty Acid Deficiency During Parenteral Soybean Oil Lipid Minimization. Journal of Perinatology, 37, 695-697. DOI: 10.1038/jp.2017.21

Vandenplas Y, Alarcon P, Badruil H, Kolacek S, Laignemet H, Raman R,  Rigo J, Salvatore S, Shamir R, Staiano A, Szajewska H, Van Goudoever J, von Berg A, Way Seah L.  Should Partial hydrolysates as standard infant formula: A working group consensus. J Pediatr Gastroenterol Nutr 2015 Oct 23 [Epub ahead of print] 2016 Jan;62(1):22-35.

Telemedicine

Makkar A, McCoy M, Hallford G, Escobedo M, Szyld E. A Hybrid Form of Telemedicine: A Unique Way to Extend Intensive Care Service to Neonates in Medically Underserved Areas. Telemed J E Health. 2018 Jan 3. doi: 10.1089/tmj.2017.0155. [Epub ahead of print]

Karp KA, Baumritter A, Pearson DJ, Pistilli M, Nyquist D, Huynh M, Satnes K, Keith R, Ying G-S, Quinn GE, for the e-ROP Cooperative Group, Training retinal imagers for Retinopathy of prematurity (ROP) screening, JAAPOS 2016;20:214-219.

SUBSTANCE AND ABUSE

Ibach, B. W.*, Johnson, P. N., Ernst, K. D., Harrison, D., Miller, J. L. (2016). Initial Dosing and Taper Complexity of Methadone and Morphine for Treatment of Neonatal Abstinence Syndrome. Journal of Pharmacy Technology, 32(5), 216-222. DOI: 10.1177/8755122516657566

Immunology and Infectious Disease

Keshari R, Silasi R, Popescu N, Patel M, Chaaban H, Lupu C, Coggeshall K, Mollnes T, DeMarco S, Lupu F, Inhibition of Complement C5 Protects Against Organ Failure and Reduces Mortality in a Baboon Model of Escherichia Coli Sepsis, Proc Nat’l Acad Sci USA. 2017 Jul 18.pii: 201706818 [epub ahead of print].

Makoni M, Eckert J, Pereira A, Nizet V, Lawrence S, , Alterations in Neonatal Neutrophil Function Attributable to Increased Immature Forms, Early Hum Dev 2016 Jul 15;103:1-7

Chaaban H, Keshari RS, Silasi-Mansat R, Popescu NI, Mehta-D’Souza P, Lim P, Lupu F, Inter-alpha Inhibitor Protein and its Associated Glycosaminoglycans Protect Against Histone-Induced Injury, Blood 2015 Jan28. Pii: blood-2014-06-582759.

Dapaah-Siakwan F, Gunasekaran A, Schutzman D, C-Reactive Protein Levels Following Hepatitis B Vaccine in Healthy Newborns, J Perinatol 2015 Nov 12.doi: 10.1038/jp.2015.160 [Epub ahead of print].

Lawrence SM, Eckert JV, Makoni M, and Pereira HA, Is the Use of Complete Blood Counts with Manual Differentials for Determining Neutrophil Composition in Newborns Antiquated? Ann Clin Lab Sci. 2015 Summer; 45(4):403-13.


The University of Oklahoma 
Department of Pediatrics
Division of Neonatal-Perinatal Medicine
PO Box 26901, Oklahoma City, OK 73126-0901
1200 Everett Drive, ETNP7504, OKC, OK 73104 
Phone: (405) 271-5215