Pre-Clinical Models

Visceral Hypersensitivity

Non-Spontaneous:

  • Acetic Acid-induced
  • Animal models of stress
    • Wrap restraint
    • Water avoidance stress
  • Amygdala implants
  • Post-inflammatory viceral hyperalgesia

Colitis

Non-Spontaneous:

  • TNBS-induces
  • Dextran Sulfate Sodium (DSS)-induced
  • Parasite-induced inflammation
  • HLA-B27 transgenic rat model

Other

  • Emesis models
  • Esophagitis model
  • Direct recording of colonic motility via a chronic cecal fistual in ambulatory mini-pigs