Amniotic Fluid

Do Not Transport Specimens In Syringes

Amniocentesis is performed in patients who have a significant risk for having a child with a chromosome abnormality. Genetic conditions can be tested for depending on the patient's family history and availability of testing. Chromosome analysis is performed on fetal cells which are present in the amniotic fluid, while alpha-fetoprotein is quantitated from the fluid itself (amniotic fluid alpha-fetoprotein or AF-AFP). An assay for the presence/absence of acetlycholinesterase (ACHE) is performed when the AF-AFP exceeds 2.0 MoMs or there is a family history of neural tube defects. To submit a specimen for genetic studies please follow the guidelines listed below.

Collect 15-20 ml of amniotic fluid for karyotyping. If the doctor is requesting FISH studies include an additional 3 ml of fluid. Sterilely transfer the fluid to a screw top centrifuge tube to ensure limited exposure of the fluid to the syringes used for collection. Keep the specimen cool but do not freeze. Before shipping, write the patient's name on the container the specimen is to be transported in. When completing the Genetics lab requisition form, please include a reason for study, and record the patient's gestational age.

This test requires a 7-10 day turn-around time.

Example of a normal male karyotype, study performed on amniotic fluid.


The links below provide access to Test Forms, CPT codes, etc.

Test Order Forms

Courier Information

CPT Codes and Pricing