Beverley Greenwood-Van Meerveld, PhD

Greenwood

Appointments:

  • Professor of Physiology 
  • Director Oklahoma Center for Neuroscience 
  • Presbyterian Health Foundation Chair in Neuroscience 
  • VA Career Scientist
  • Adjunct Professor of Pharmaceutical Sciences
  • Adjunct Professor of Psychiatry & Behavioral Sciences

Special lnterests:

To advance the science and understanding of brain-gut interactions by the best possible research and pursuing interdisciplinary synergistic collaborations to take advantage of cutting edge technologies, and innovative research approaches to treat gastrointestinal disorders such as irritable bowel syndrome, post-operative ileus and gastroparesis.

Training:

  • BSc. with Special Honors: Physiology, University of Sheffield, U.K. (1977-80) 
  • Ph.D. GI Neurophysiology, University of Sheffield, U.K. (1980-83) 
  • Alberta Heritage Postdoctoral Research Fellow Gastrointestinal (GI) Research, University of Calgary, Canada (1983-86) 

Research Summary:

In my capacity as a Professor of Physiology, Director of the Oklahoma Center for Neuroscience (OCNS), Presbyterian Health Foundation Endowed Chair in Neuroscience and VA Career Scientist at the University of Oklahoma Health Sciences Center (OUHSC). I am actively involved in research currently serving as the PI on two active VA grants, Co-Investigator on a recently completed NIH P20 grant, and PI on multiple industry-sponsored contracts. I have an extensive publication record with 144 peer-reviewed manuscripts. My research productivity and international reputation in the field has been recognized by receipt of the 2004 Janssen Award for Basic Research in Digestive Diseases and the 2012 University of Oklahoma Regents Award for Superior Research and Creative Activity. My research interest focuses on the central nervous system regulation of visceral pain with a strategic objective of using preclinical models and multiple state-of-the-art techniques, from molecular and cellular to behavioral, pharmacological and electrophysiological methods to address a series of key and important questions.  My group is interested in understanding how the brain regulates the gastrointestinal tract. With the aid of behavioral, pharmacological, molecular and electrophysiological methods we are examining the:- a) Role of amygdala-mediated mechanisms in the control of visceral and somatic pain b) Importance of early life adverse experience on visceral and somatic pain in adulthood c) Sex-related differences in the relationship between visceral pain and anxiety. In addition to our work on brain-gut interactions, we also investigate the effects of novel pharmacological approaches to treat gastrointestinal disorders.   

As Director of the Oklahoma Center for Neuroscience at OUHSC I am involved in student education, curriculum development and the professional growth of the graduate students in the Neuroscience program.  Additionally, I currently serve as the course-director for the MS-1 Gastrointestinal Hepatobiliary systems and in 2014 was inducted into the OUHSC College of Medicine Academy of Teaching Scholars.

Recent Publications (from a total of 139 peer reviewed publications/reviews and book chapters/reviews and 9 US patents)

  • Mohammadi E, Prusador D, Healing E, Hurst R, Towner R, Wisniewski AB, Greenwood-Van        Meerveld B. (2016) Sexually Dimorphic Effects of Early Life Stress on Bladder Contractility in Adulthood.  Biology of Sex Differences 7:8 pages 1-10.

  • Towner RA, Wisniewski, AB, Wu DH, Van Gordon SB, Smith N, North JC, McElhaney R, Aston CE, Shobeiri A, Kropp BP, Greenwood-Van Meerveld B., Hurst RE. (2016) Feasibility of using Clinical Contrast-Enhanced MRI to Quantify Bladder Permeability Associated with Interstitial Cystitis J. Urol. 195(3):631-8.

  • Ligon CO, Moloney RD, Greenwood-Van Meerveld B. (2016) Targeting Epigenetic Mechanisms for Chronic Pain: A Valid Approach for the Development of Novel Therapeutics. Invited Mini Review J. Pharm. Exp. Therap. 357(1):84-93.

  • Greenwood-Van Meerveld B, Moloney RD, Johnson AC, Vicario M.  (2016) Mechanisms of stress-induced visceral pain: implications in irritable bowel syndrome. J. Neuroendocrinology (in press).

  • Hurst R, Van Gorden S, Tyler K, Mohammadi E, Kropp B, Towner R., Lin HK, Marentette J, McHowat J, Greenwood-Van Meerveld B. (2016) In the Absence of Overt Urothelial Damage, Chondroitinase Digestion of the GAG Layer or Neutralization with Dilute Protamine Sulfate Increases Bladder Permeability in Rats. Am. J. Physiol (in press).

  • Prusador D, Greenwood-Van Meerveld B. (2016) Comparison of Nociceptive Behaviors in Adult Rats Following Three Early Life Stress Paradigms. Biology of Sex Differences (in press).

  • Prusador D, Greenwood-Van Meerveld B. (2016) Sex Differences in Stress-Induced Visceral       Hypersensitivity Following Early Life Adversity: A Two Hit Model.  Neurogastroenterol. Mot. (in press).

  • Latorre R, Sternini C, De Giorgio R, Greenwood-Van Meerveld B. (2016). Enteroendocrine Cells: A Review of Their Role In Brain-Gut Communication.  Neurogastroenterol. Mot. (in press).

  • Vanner S, Greenwood-Van Meerveld B, Mawe GM, Shea-Donohue T, Verdu E, Wood J and Grundy D. (2016) Fundamentals of Neurogastroenterology: Basic Science. Gastroenterology (in press).

  • Prusador D, Andrews A, Greenwood-Van Meerveld B. (2016) Neurobiology of Early Life Stress and Visceral Pain: Translational Relevance From Animal Models to Patient Care. Neurogastroenterol. Mot. (in press).

  • Greenwood-Van Meerveld B. Prusador D, Johnson AC. (2015) Animal Models of Visceral Pain: Pathophysiology Translational Relevance and Challenges (Invited Review).   Am. J. Physol. 308 (11):G885-903.

  • Johnson AJ, Tran L, Greenwood-Van Meerveld B. (2015) Knockdown of Corticotropin- Releasing Factor in the Central Amygdala Reverses Chronic Hyperalgesia.Translational Psychiatry  93:116-123.

  • Johnson AJ and Greenwood-Van Meerveld B. (2015) Knockdown of steroid receptors in the central nucleus of the amygdala induces heightened pain behaviors in the rat. Neuropharmacology 9:116-23.

  • Towner RA, Smith N, Saunders D, Van Gordon SB, Wisniewski AB, Tyler K, Greenwood-Van Meerveld B., Hurst RE. (2015) Contrast-Enhanced Magnetic Resonance Imaging (CE-MRI) as a Diagnostic Tool for Assessing Bladder Permeability and Associated Colon Cross-Talk: Pre-Clinical Studies in a Rat Model. J. Urol. 193 (4):1394-400.

  • Prusador D, Greenwood-Van Meerveld B. (2015) Gender Specific Effects of Neonatal Limited    Nesting on Viscerosomatic Sensitivity and Anxiety-Like Behavior in Adult Rats.  Neurogastroenterology and Motility 27 (1):72-81.

  • Tran L, Schulkin J, Greenwood-Van Meerveld B. (2014) Epigenetic Modulation of Chronic Anxiety and Pain by Histone Deacetylation.  Molecular Psychiatry 20 (10):1219-31 .

http://find.ouhsc.edu/Faculty.aspx?FacultyID=183

Funding Agencies: Department of Veteran’s Affairs and various Pharmaceutical Companies (various) 

Contact:

Office telephone: (405) 456-3547
Email: Beverley-Greenwood@ouhsc.edu