Dr. Sun's teaching interests include integrative cardiovascular/renal physiology and genomics. He mentors graduate students and trains postdoctoral fellows in a broad area of physiology (cardiovascular, renal and endocrine physiology). Dr. Sun has a unique vision for training graduate students. In his lab, graduate students and postdoctors are trained for integrative physiology that includes whole animal, cellular, and molecular research; thus they are prepared to be leaders in biological and biomedical sciences in the 21st century, and to teach traditional systems physiology.
Graduate students, medical students, undergraduate students, and high school students are welcome to join Dr. Sun's lab for research training. The Sun lab has a dynamic, creative, and productive research team in cardiovascular/renal physiology and neuroscience
Dr. Sun's research interests are in the study of molecular and cellular mechanisms involved in the regulation of blood pressure. Application of molecular, transgenic and integrative approaches to the understanding of complex physiological function represents the central theme of most of his current research. His recent effort is on the identification and characterization of genetic and environmental factors and their interaction in the pathogenesis of hypertension and diabetes.
SELECTED RECENT PUBLICATIONS
1. Patrick Crosswhite and Zhongjie Sun. Inhibition of phosphodiesterase 1attenuates cold-induced pulmonary hypertension. Hypertension. 61:585-592,2013.
2. Xiuqing Wang, Lucille Skelley, Bo Wang, Ayesha Mejia, Val Sapozhnikov and Zhongjie Sun. AAV-based RNAi silencing of NADPH oxidase gp91phox attenuates cold-induced cardiovascular dysfunction. Human Gene Ther. 23(9):1016-1026, 2012
3. Xiuqing Wang and Zhongjie Sun. Normal IgG downregulates the intracellular superoxide and attenuates migration and permeability in human aortic endothelial cells from a hypertensive patient. Hypertension. 60:818-826, 2012.
4. Yuhong Wang and Zhongjie Sun. Klotho suppresses NADPH oxidase activity and superoxide production in rat aortic smooth muscle cells. Aging Cell. 11(3):410-417, 2012.
5. Yi Lin, and Zhongjie Sun. Klotho enhances glucose-induced insulin secretion in Min6 β cells by upregulating plasma membrane retention of TRPV2. Endocrinology. 153(7):3029-3039, 2012.
6. Yi Lin and Zhongjie Sun. T3 enhances insulin-induced glucose uptake via the Akt-VAMP2 pathway in 3T3-L1 adipocytes. J Cell Physiol. 226:2625-2632, 2011.
7. Yi Lin and Zhongjie Sun. Thyroid hormone potentiates insulin signaling, attenuates hyperglycemia and reverses insulin resistance in type II diabetes. British J Pharmacol. 162(3):597-610, 2010.
8. Patrick Crosswhite and Zhongjie Sun. RNA inhibition of interleukin-6 gene attenuates cold-induced hypertension. Hypertension. 55:1484-1491, 2010.
9. Xiuqing Wang and Zhongjie Sun. RNAi inhibition of brain klotho potentiates cold-induced elevation of blood pressure. Physiol Genom. PMCID: 20086041 (Epub ahead of print, in press, 2010).
10. Xiuqing Wang and Zhongjie Sun. Thyroid hormone induces vascular smooth muscle cell proliferation through a new TRα1-Nox1 pathway. J Cell Mol Med. 14(2):368-380, 2010.
Office telephone: (405) 271-2226 x 56237