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Current and Previous Members of Guo Lab

 


Dr. Qing Guo is Professor of Physiology, and Principal Investigator of the NIH-funded Laboratory of Signaling of Cell Death in Physiology and Disease. He has published extensively in the area of molecular biology of cell death, and is nationally and internationally recognized for his work related to apoptosis in neurodegenerative diseases. His lab also investigates the cell death mechanisms in other organ systems outside the central nervous system, including apoptotic mechanisms in renal tubular epithelial cells. Contact Dr. Guo at: qing-guo@ouhsc.edu

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Sima Asfa
is a laboratory technician. She joined Dr. Guo’s lab in March of 2016. She is working on a project funded by Harold Hamm Diabetes Center to study the cell death mechanisms in diabetic nephropathy. She has many years of experience in working with laboratory animals and has co-authored several papers in the field using in vitro and in vivo models of diabetes. Contact Sima at: sima-asfa@ouhsc.edu

 

 

 

Dr. Jun Xie is Associate Professor of Research in the Department of Physiology. She graduated from medical school and specialized in clinical neurology and psychiatry. She has over 3 years of clinical experience in psychiatry and over 15 years of experience working in molecular and cell biology research labs, and is skillful in an array of lab research techniques. She has published many original research papers on the mechanisms of cell death using in vitro and in vivo models of human diseases. Dr. Xie's major research interests have been focused on the characterization of cell death pathways in transgenic models of human diseases.
Contact Jun at: jun-xie@ouhsc.edu  

 

 

Dr. Najeeb A. Shirwany got his medical degree in Dow University of Health Sciences in Karachi, Pakistan in 1985. He was a research/postdoctoral fellow in the Department of Otolaryngology at Henry Ford Heath System in Detroit, Michigan during 1995-1998. He joined Dr. Guo's lab at OUHSC in 2005 as a graduate student. His primary research interest is to look at the functional properties of the voltage-independent, poorly selective Abeta channel and how it is related to the pathogenesis of Alzheimer's disease. His studies involve patch clumping electrophysiology, and cellular and molecular techniques in gene transfer and protein expression. He has also investigated the neurotoxic properties of Abeta peptides in comparison to their amyloidogenic properties in transgenic mice. Contact Najeeb at: najeeb-shirwany@ouhsc.edu

 

 

Daniel Payette was a graduate research assistant. He joined Dr. Guo's lab in 2004. His major area of research was focused on molecular regulators of choline uptake and application of neural stem cells in the treatment of brain trauma. He also examined the roles of the leucine zipper proteins Par-4 and AATF at molecular and cellular levels. He employed cell culture, gene transfer and expression protocols, and transgenic mouse models in his studies. He published several original research papers and a review article. He graduated in 2008 from Dr. Guo's lab as a member of Oklahoma Center for Neuroscience (OCNS).

 

 

Chelsea Ann Baker was a graduate student in Dr. Guo's lab. She joined Dr. Guo's lab in April of 2008. Her major area of research was focused on molecular regulators of renal cell death in diabetic nephropathy. She was particularly interested in studying the specific involvement of cell death/survival proteins, such as prostate apoptosis response-4 (Par-4) and apoptosis antagonizing transcription factor (AATF) in the pathogenesis of diabetic nephropathy at molecular and cellular levels. She now continues her graduate education at the College of Public Health at OUHSC.
Contact Chelsea at: chelsea-baker@ouhsc.edu

 

 

Keytam Awad was a graduate student at NEOUCOM. Her major area of research in Dr. Guo's lab was focused on molecular regulators of neuronal cell death in transgenic models of ALS. She was particularly interested in studying the specific involvement of cell death/survival proteins, such as prostate apoptosis response-4 (Par-4) and apoptosis antagonizing transcription factor (AATF) in the pathogenesis of neuronal cell death in ALS at molecular and cellular levels. She is now a postdoctoral fellow at the University of Florida.

 

 

Sandeep Bhatt was a graduate student at NEOUCOM. His major area of research in Dr. Guo's lab was focused on molecular regulators of neuronal cell death in transgenic models of AD.

 

 

Ling Yang was a graduate student in Dr. Guo's labs at NEOUCOM and OUHSC. Her major area of research in Dr. Guo's lab was focused on molecular regulators of neuronal cell death in transgenic models of AD. Her work focused on AATF, a transcription factor with anti-apoptotic properties. She is now a postdoctoral fellow at Harvard School of Public Health.

 

 

Huimin Du was a Research Assistant in Dr. Guo's lab at NEOUCOM. Her major area of research was focused on molecular regulators of neuronal cell survival and death in transgenic models of AD.

 

 

Xiaowei Chang was a Research Assistant in Dr. Guo's lab at NEOUCOM. Her major area of research was focused on molecular regulators of neuronal cell survival and death in transgenic models of AD.

 

 

Mngyuan Wu was a graduate student in Dr. Guo's lab at NEOUCOM and OUHSC until late 2003. His major area of research in Dr. Guo's lab was focused on the effects of traditional Chinese medicine on neuronal survival in primary neurons.