Selected Publications from Guo Lab

  • Najeeb A Shiwany, Jun Xie and Qing Guo. Cortical neurons transgenic for human Aβ40 or Aβ42 have similar vulnerability to apoptosis despite their different amyloidogenic properties. Int J Clin Exp Pathol 2(4); 2009; 339-352.
  • Daniel J. Payette, Jun Xie, Najeeb Shirwany, and Qing Guo. Exacerbation of apoptosis of cortical neurons following traumatic brain injury in Par-4 transgenic mice. Int J Clin Exp Pathol 2008; 1: 44-56
  • Najeeb A Shirwany, Daniel Payette, Jun Xie, and Qing Guo. The amyloid beta ion channel hypothesis of Alzheimer’s disease: A review. Neuropsychiatric Disease and Treatment. 2007: 3(5) 597-612.
  • Jun Xie, and Qing Guo. Par-4 is Novel Mediator of Renal Tubule Cell Death in Models of Ischemia-Reperfusion Injury. Am. J. Physiol. Renal Physiol., 2007; 292(1): F107-F115.
  • Jun Xie, and Qing Guo. Apoptosis Antagonizing Transcription Factor Protects Renal Tubule Cells against Oxidative Damage and Apoptosis Induced by Ischemia-Reperfusion. J. Am. Soc. Nephrol. 2006; 17(12): 3336-3346.
  • Jun Xie, and Qing Guo. Par-4 Is involved in regulation of beta -secretase cleavage of the Alzheimer’s amyloid precursor protein. J Biol Chem., 2005; 280(14): 13824-13832.
  • Jun Xie, Keytam S. Awad, and Qing Guo. RNAi knockdown of Par-4 inhibits neurosynaptic degeneration in ALS-linked mice. J Neurochem. 2005; 92, 59-71.
  • Jun Xie, and Qing Guo. AATF protects neural cells against oxidative damage induced by amyloid beta-peptide. Neurobiol Dis 2004; 16, 150-157.
  • Jun Xie, and Qing Guo. Par-4 inhibits choline uptake by interacting with CHT1 and reducing its incorporation on the plasma membrane. J Biol Chem 2004; 279, 28266-28275.
  • Qing Guo, and Xie, J. AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4. J Biol Chem 2004; 279, 4596-4603
  • Qing Guo, Jun Xie, Xiaowei Chang, and Huimin Du. Prostate Apoptosis Response-4 Enhances Secretion of Amyloid beta Peptide 1-42 in Human Neuroblastoma IMR-32 Cells by a Caspase-dependent Pathway. J. Biol. Chem. 2001; 276: 16040-16044
  • Qing Guo, Weiming Fu, Bryce Sopher, Miles W. Miller, Carol B. Ware, George M. Martin, and Mark P. Mattson. Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice. Nature Medicine 1999; 5: 101-107.
  • Qing Guo, Lois Sebastian, Bryce Sopher, Miles W. Miller, Gordon W. Glazner, Carol B. Ware, George M. Martin, and Mark P. Mattson. Neurotrophic factors (ADNF and bFGF) interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation. Proc. Natl. Acad. Sci. USA. 1999; 96(7): 4125-4130
  • Qing Guo, Weiming Fu, Jun Xie, Hong Luo, Stephen J. Sells, James W. Geddes, Vimala Bondada, Vivek M. Rangnekar and Mark P. Mattson. Par-4 is a new mediator of neuronal degeneration associated with the pathogenesis of Alzheimer’s disease. Nature Medicine 1998; August, 4(8): 957-962
  • Qing Guo, Sylvia Christakos, Nic Robinson and Mark P. Mattson. Calbindin D28K Blocks the Pro-Apoptotic Actions of Mutant Presenilin-1: Reduced Oxidative Stress and Preserved Mitochondrial Function. Proc. Natl. Acad. Sci. USA. 1998; 95:3227-3232.
  • Qing Guo, Nic Robinson and Mark P. Mattson. Secreted beta-amyloid precursor protein counteracts the pro-apoptotic action of mutant presenilin-1 by activation of NF-kB and stabilization of calcium homeostasis. J. Biol. Chem. 1998; 273 (20): 12341-12351.
  • Jeffrey N. Keller, Qing Guo, F.W. Holtsberg, A.J. Bruce-Keller, and Mark P. Mattson. Increased sensitivity to mitochondrial toxin-induced apoptosis in neural cells expressing mutant presenilin-1 in linked to perturbed calcium homeostasis and enhanced oxyradical production. J. Neurosci. 1998; 18(12): 4439-4450.
  • Qing Guo, Bryce L. Sopher, Katsutoshi Furukawa, Dao G. Pham, George M. Martin and Mark P. Mattson. Alzheimer's PS-1 mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: Involvement of calcium and oxyradicals. J. Neurosci. 1997; 17(11): 4212-4222
  • Ward A. Peterson, Qing Guo, Boyd K. Hartmans, and Mark P. Mattson. Nerve growth factor-independent reduction in choline acetyltransferase activity in PC12 cells expressing mutant presenilin-1. J. Biol. Chem. 1997; 272(36): 22397-22400